Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
3R01NS030570-03S1
Application #
2268528
Study Section
Neurological Sciences Subcommittee 1 (NLS)
Project Start
1992-12-01
Project End
1996-11-30
Budget Start
1994-12-01
Budget End
1995-11-30
Support Year
3
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Montana
Department
Other Health Professions
Type
Schools of Pharmacy
DUNS #
City
Missoula
State
MT
Country
United States
Zip Code
59812
Ahmed, S Kaleem; Etoga, Jean-Louis G; Patel, Sarjubhai A et al. (2011) Use of the hydantoin isostere to produce inhibitors showing selectivity toward the vesicular glutamate transporter versus the obligate exchange transporter system x(c)(-). Bioorg Med Chem Lett 21:4358-62
Etoga, Jean-Louis G; Ahmed, S Kaleem; Patel, Sarjubhai et al. (2010) Conformationally-restricted amino acid analogues bearing a distal sulfonic acid show selective inhibition of system x(c)(-) over the vesicular glutamate transporter. Bioorg Med Chem Lett 20:2680-3
Patel, Sarjubhai A; Rajale, Trideep; O'Brien, Erin et al. (2010) Isoxazole analogues bind the system xc- transporter: structure-activity relationship and pharmacophore model. Bioorg Med Chem 18:202-13
Ye, Ran; Rhoderick, Joseph F; Thompson, Charles M et al. (2010) Functional expression, purification and high sequence coverage mass spectrometric characterization of human excitatory amino acid transporter EAAT2. Protein Expr Purif 74:49-59
Mavencamp, Terri L; Rhoderick, Joseph F; Bridges, Richard J et al. (2008) Synthesis and preliminary pharmacological evaluation of novel derivatives of L-beta-threo-benzylaspartate as inhibitors of the neuronal glutamate transporter EAAT3. Bioorg Med Chem 16:7740-8
Queen, Susan A; Kesslak, J Patrick; Bridges, Richard J (2007) Regional distribution of sodium-dependent excitatory amino acid transporters in rat spinal cord. J Spinal Cord Med 30:263-71
Bridges, Richard J; Esslinger, C Sean (2005) The excitatory amino acid transporters: pharmacological insights on substrate and inhibitor specificity of the EAAT subtypes. Pharmacol Ther 107:271-85
Esslinger, C Sean; Agarwal, Shailesh; Gerdes, John et al. (2005) The substituted aspartate analogue L-beta-threo-benzyl-aspartate preferentially inhibits the neuronal excitatory amino acid transporter EAAT3. Neuropharmacology 49:850-61
Patel, Sarjubhai A; Warren, Brady A; Rhoderick, Joseph F et al. (2004) Differentiation of substrate and non-substrate inhibitors of transport system xc(-): an obligate exchanger of L-glutamate and L-cystine. Neuropharmacology 46:273-84
Warren, Brady A; Patel, Sarjubhai A; Nunn, Peter B et al. (2004) The Lathyrus excitotoxin beta-N-oxalyl-L-alpha,beta-diaminopropionic acid is a substrate of the L-cystine/L-glutamate exchanger system xc-. Toxicol Appl Pharmacol 200:83-92

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