Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
2R01NS030652-04
Application #
2268616
Study Section
Neurology A Study Section (NEUA)
Project Start
1993-08-01
Project End
2000-05-31
Budget Start
1996-08-28
Budget End
1997-05-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Cincinnati
Department
Neurology
Type
Schools of Medicine
DUNS #
City
Cincinnati
State
OH
Country
United States
Zip Code
45221
Lu, Aigang; Clark, Joseph F; Broderick, Joseph P et al. (2009) Mechanical reperfusion is associated with post-ischemic hemorrhage in rat brain. Exp Neurol 216:407-12
Clark, J F; Loftspring, M; Wurster, W L et al. (2008) Bilirubin oxidation products, oxidative stress, and intracerebral hemorrhage. Acta Neurochir Suppl 105:7-12
Lu, Aigang; Clark, Joseph F; Broderick, Joseph P et al. (2008) Reperfusion activates metalloproteinases that contribute to neurovascular injury. Exp Neurol 210:549-59
Loftspring, Matthew C; Clark, Joseph F; Wagner, Kenneth R (2007) A novel duplex ELISA method for quantitation of plasma proteins in areas of brain edema. Brain Res 1162:130-2
Wagner, Kenneth R (2007) Modeling intracerebral hemorrhage: glutamate, nuclear factor-kappa B signaling and cytokines. Stroke 38:753-8
Loftspring, Matthew C; Beiler, Shauna; Beiler, Christian et al. (2006) Plasma proteins in edematous white matter after intracerebral hemorrhage confound immunoblots: an ELISA to quantify contamination. J Neurotrauma 23:1904-11
Wagner, K R; Beiler, S; Beiler, C et al. (2006) Delayed profound local brain hypothermia markedly reduces interleukin-1beta gene expression and vasogenic edema development in a porcine model of intracerebral hemorrhage. Acta Neurochir Suppl 96:177-82
Wagner, Kenneth R; Dean, Christopher; Beiler, Shauna et al. (2005) Plasma infusions into porcine cerebral white matter induce early edema, oxidative stress, pro-inflammatory cytokine gene expression and DNA fragmentation: implications for white matter injury with increased blood-brain-barrier permeability. Curr Neurovasc Res 2:149-55
Wagner, Kenneth R; Zuccarello, Mario (2005) Local brain hypothermia for neuroprotection in stroke treatment and aneurysm repair. Neurol Res 27:238-45
Wagner, Kenneth R; Jauch, Edward C (2004) Extending the window for acute stroke treatment: thrombolytics plus CNS protective therapies. Exp Neurol 188:195-9

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