Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS031602-03
Application #
2269536
Study Section
Neurological Sciences Subcommittee 1 (NLS)
Program Officer
Kitt, Cheryl A
Project Start
1994-05-01
Project End
1998-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Tufts University
Department
Pharmacology
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02111

  Publications

Beinfeld, Margery C; Funkelstein, Lydiane; Foulon, Thierry et al. (2009) Cathepsin L plays a major role in cholecystokinin production in mouse brain cortex and in pituitary AtT-20 cells: protease gene knockout and inhibitor studies. Peptides 30:1882-91
Reynolds, Nicole A; Blum, Alissa; Kitagawa, Kouki et al. (2006) Inhibition of PC5 expression decreases CCK secretion and increases PC2 expression. Peptides 27:901-4
Burgdorf, Jeffrey; Panksepp, Jaak; Beinfeld, Margery C et al. (2006) Regional brain cholecystokinin changes as a function of rough-and-tumble play behavior in adolescent rats. Peptides 27:172-7
Beinfeld, Margery C; Vishnuvardhan, Daesety; Blum, Alissa et al. (2006) Inhibition of prohormone convertase 1 (PC1) expression in cholecystokinin (CCK) expressing At-T20 cells decreased cellular content and secretion of CCK and caused a shift in molecular forms of CCK secreted. Peptides 27:905-10
Beinfeld, Margery C; Blum, Alissa; Vishnuvardhan, Daesety et al. (2005) Cholecystokinin levels in prohormone convertase 2 knock-out mouse brain regions reveal a complex phenotype of region-specific alterations. J Biol Chem 280:38410-5
Tagen, Michael B; Beinfeld, Margery C (2005) Recombinant prohormone convertase 1 and 2 cleave purified pro cholecystokinin (CCK) and a synthetic peptide containing CCK 8 Gly Arg Arg and the carboxyl-terminal flanking peptide. Peptides 26:2530-5
Cadel, Sandrine; Gouzy-Darmon, Cecile; Petres, Stephane et al. (2004) Expression and purification of rat recombinant aminopeptidase B secreted from baculovirus-infected insect cells. Protein Expr Purif 36:19-30
Cain, B M; Connolly, K; Blum, A C et al. (2004) Genetic inactivation of prohormone convertase (PC1) causes a reduction in cholecystokinin (CCK) levels in the hippocampus, amygdala, pons and medulla in mouse brain that correlates with the degree of colocalization of PC1 and CCK mRNA in these structures J Neurochem 89:307-13
Kleditzsch, Petra; Pratt, John; Vishnuvardhan, Daesety et al. (2003) Production, purification, and characterization of rat pro-CCK from serum-free adapted Drosophila cells. Protein Expr Purif 31:56-63
Cain, Brian M; Connolly, Kelly; Blum, Alissa et al. (2003) Distribution and colocalization of cholecystokinin with the prohormone convertase enzymes PC1, PC2, and PC5 in rat brain. J Comp Neurol 467:307-25

Showing the most recent 10 out of 30 publications