Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS031763-03
Application #
2269710
Study Section
Mammalian Genetics Study Section (MGN)
Project Start
1994-05-01
Project End
1997-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Tel Aviv University
Department
Type
DUNS #
City
Tel Aviv
State
Country
Israel
Zip Code
69978
Rasmussen, Lene Juel; Shiloh, Yosef; Bergersen, Linda H et al. (2013) DNA damage response, bioenergetics, and neurological disease: the challenge of maintaining brain health in an aging human population. Mech Ageing Dev 134:427-33
Biton, Sharon; Gropp, Michal; Itsykson, Pavel et al. (2007) ATM-mediated response to DNA double strand breaks in human neurons derived from stem cells. DNA Repair (Amst) 6:128-34
Dar, Inbal; Biton, Sharon; Shiloh, Yosef et al. (2006) Analysis of the ataxia telangiectasia mutated-mediated DNA damage response in murine cerebellar neurons. J Neurosci 26:7767-74
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Ziv, Yael; Bielopolski, Dana; Galanty, Yaron et al. (2006) Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway. Nat Cell Biol 8:870-6
Pereg, Yaron; Lam, Suzanne; Teunisse, Amina et al. (2006) Differential roles of ATM- and Chk2-mediated phosphorylations of Hdmx in response to DNA damage. Mol Cell Biol 26:6819-31
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Blank, Michael; Lerenthal, Yaniv; Mittelman, Leonid et al. (2006) Condensin I recruitment and uneven chromatin condensation precede mitotic cell death in response to DNA damage. J Cell Biol 174:195-206
Okamoto, Koji; Kashima, Kenji; Pereg, Yaron et al. (2005) DNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation. Mol Cell Biol 25:9608-20
Ziv, Shelly; Brenner, Ori; Amariglio, Ninette et al. (2005) Impaired genomic stability and increased oxidative stress exacerbate different features of Ataxia-telangiectasia. Hum Mol Genet 14:2929-43

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