Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
1R01NS033912-01A1
Application #
2272954
Study Section
Special Emphasis Panel (ZRG1-NEUC (01))
Project Start
1996-04-22
Project End
2000-02-29
Budget Start
1996-04-22
Budget End
1997-02-28
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Medicine & Dentistry of NJ
Department
Neurosciences
Type
Schools of Medicine
DUNS #
605799469
City
Newark
State
NJ
Country
United States
Zip Code
07107
Wu, Gusheng; Lu, Zi-Hua; André, Sabine et al. (2016) Functional interplay between ganglioside GM1 and cross-linking galectin-1 induces axon-like neuritogenesis via integrin-based signaling and TRPC5-dependent Ca(2+) influx. J Neurochem 136:550-63
Hadaczek, Piotr; Wu, Gusheng; Sharma, Nitasha et al. (2015) GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model. Exp Neurol 263:177-89
Wu, Gusheng; Lu, Zi-Hua; Kulkarni, Neil et al. (2012) Deficiency of ganglioside GM1 correlates with Parkinson's disease in mice and humans. J Neurosci Res 90:1997-2008
Ledeen, Robert; Wu, Gusheng (2011) New findings on nuclear gangliosides: overview on metabolism and function. J Neurochem 116:714-20
Wu, Gusheng; Lu, Zi-Hua; Kulkarni, Neil et al. (2011) Mice lacking major brain gangliosides develop parkinsonism. Neurochem Res 36:1706-14
Wang, Jianfeng; Lu, Zi-Hua; Gabius, Hans-Joachim et al. (2009) Cross-linking of GM1 ganglioside by galectin-1 mediates regulatory T cell activity involving TRPC5 channel activation: possible role in suppressing experimental autoimmune encephalomyelitis. J Immunol 182:4036-45
Wang, Jianfeng; Wu, Gusheng; Miyagi, Taeko et al. (2009) Sialidase occurs in both membranes of the nuclear envelope and hydrolyzes endogenous GD1a. J Neurochem 111:547-54
Wu, Gusheng; Xie, Xin; Lu, Zi-Hua et al. (2009) Sodium-calcium exchanger complexed with GM1 ganglioside in nuclear membrane transfers calcium from nucleoplasm to endoplasmic reticulum. Proc Natl Acad Sci U S A 106:10829-34
Ledeen, Robert W; Wu, Gusheng (2008) Nuclear sphingolipids: metabolism and signaling. J Lipid Res 49:1176-86
Ledeen, Robert; Wu, Gusheng (2007) GM1 in the nuclear envelope regulates nuclear calcium through association with a nuclear sodium-calcium exchanger. J Neurochem 103 Suppl 1:126-34

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