Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
1R01NS034100-01A1
Application #
2037948
Study Section
Neurological Sciences Subcommittee 1 (NLS)
Project Start
1996-09-10
Project End
1999-05-31
Budget Start
1996-09-10
Budget End
1997-05-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Pathology
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Martin, Lee J; Wong, Margaret (2017) Enforced DNA repair enzymes rescue neurons from apoptosis induced by target deprivation and axotomy in mouse models of neurodegeneration. Mech Ageing Dev 161:149-162
Chang, Qing; Martin, Lee J (2016) Voltage-gated calcium channels are abnormal in cultured spinal motoneurons in the G93A-SOD1 transgenic mouse model of ALS. Neurobiol Dis 93:78-95
Martin, Lee J; Semenkow, Samantha; Hanaford, Allison et al. (2014) Mitochondrial permeability transition pore regulates Parkinson's disease development in mutant ?-synuclein transgenic mice. Neurobiol Aging 35:1132-52
Martin, Lee J; Fancelli, Daniele; Wong, Margaret et al. (2014) GNX-4728, a novel small molecule drug inhibitor of mitochondrial permeability transition, is therapeutic in a mouse model of amyotrophic lateral sclerosis. Front Cell Neurosci 8:433
Martin, Lee J (2012) Biology of mitochondria in neurodegenerative diseases. Prog Mol Biol Transl Sci 107:355-415
Martin, Lee J; Chang, Qing (2012) Inhibitory synaptic regulation of motoneurons: a new target of disease mechanisms in amyotrophic lateral sclerosis. Mol Neurobiol 45:30-42
Gertz, Barry; Wong, Margaret; Martin, Lee J (2012) Nuclear localization of human SOD1 and mutant SOD1-specific disruption of survival motor neuron protein complex in transgenic amyotrophic lateral sclerosis mice. J Neuropathol Exp Neurol 71:162-77
Martin, Lee J (2011) Mitochondrial pathobiology in ALS. J Bioenerg Biomembr 43:569-79
Northington, Frances J; Chavez-Valdez, Raul; Martin, Lee J (2011) Neuronal cell death in neonatal hypoxia-ischemia. Ann Neurol 69:743-58
Chang, Qing; Martin, Lee J (2011) Glycine receptor channels in spinal motoneurons are abnormal in a transgenic mouse model of amyotrophic lateral sclerosis. J Neurosci 31:2815-27

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