Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS034400-02
Application #
2273621
Study Section
Neurology C Study Section (NEUC)
Project Start
1995-08-29
Project End
1999-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Rochester
Department
Pharmacology
Type
Schools of Dentistry
DUNS #
208469486
City
Rochester
State
NY
Country
United States
Zip Code
14627

  Publications

Lomb, David J; Desouza, Lynette A; Franklin, James L et al. (2009) Prolyl hydroxylase inhibitors depend on extracellular glucose and hypoxia-inducible factor (HIF)-2alpha to inhibit cell death caused by nerve growth factor (NGF) deprivation: evidence that HIF-2alpha has a role in NGF-promoted survival of sympathetic neur Mol Pharmacol 75:1198-209
Guo, Y; Schoell, M C; Freeman, R S (2009) The von Hippel-Lindau protein sensitizes renal carcinoma cells to apoptotic stimuli through stabilization of BIM(EL). Oncogene 28:1864-74
Xie, Liang; Xiao, Kunhong; Whalen, Erin J et al. (2009) Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL. Sci Signal 2:ra33
Barone, Maria Cecilia; Desouza, Lynette A; Freeman, Robert S (2008) Pin1 promotes cell death in NGF-dependent neurons through a mechanism requiring c-Jun activity. J Neurochem 106:734-45
Lomb, David J; Straub, Jennifer A; Freeman, Robert S (2007) Prolyl hydroxylase inhibitors delay neuronal cell death caused by trophic factor deprivation. J Neurochem 103:1897-906
Brookes, Paul S; Freeman, Robert S; Barone, Maria Cecilia (2006) A shortcut to mitochondrial signaling and pathology: a commentary on ""Nonenzymatic formation of succinate in mitochondria under oxidative stress"". Free Radic Biol Med 41:41-5
Freeman, Robert S; Barone, Maria Cecilia (2005) Targeting hypoxia-inducible factor (HIF) as a therapeutic strategy for CNS disorders. Curr Drug Targets CNS Neurol Disord 4:85-92
Xie, Liang; Johnson, Randall S; Freeman, Robert S (2005) Inhibition of NGF deprivation-induced death by low oxygen involves suppression of BIMEL and activation of HIF-1. J Cell Biol 168:911-20
Freeman, Robert S; Burch, Robert L; Crowder, Robert J et al. (2004) NGF deprivation-induced gene expression: after ten years, where do we stand? Prog Brain Res 146:111-26
Besirli, C G; Deckwerth, T L; Crowder, R J et al. (2003) Cytosine arabinoside rapidly activates Bax-dependent apoptosis and a delayed Bax-independent death pathway in sympathetic neurons. Cell Death Differ 10:1045-58

Showing the most recent 10 out of 19 publications