Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
2R01NS034407-05
Application #
2902062
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Program Officer
Talley, Edmund M
Project Start
1995-07-01
Project End
2004-06-30
Budget Start
1999-08-15
Budget End
2000-06-30
Support Year
5
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
California Institute of Technology
Department
Type
Schools of Engineering
DUNS #
078731668
City
Pasadena
State
CA
Country
United States
Zip Code
91125

  Publications

Mosesso, Richard; Dougherty, Dennis A (2018) A triad of residues is functionally transferrable between 5-HT3 serotonin receptors and nicotinic acetylcholine receptors. J Biol Chem 293:2903-2914
Post, Michael R; Tender, Gabrielle S; Lester, Henry A et al. (2017) Secondary Ammonium Agonists Make Dual Cation-? Interactions in ?4?2 Nicotinic Receptors. eNeuro 4:
Post, Michael R; Lester, Henry A; Dougherty, Dennis A (2017) Probing for and Quantifying Agonist Hydrogen Bonds in ?6?2 Nicotinic Acetylcholine Receptors. Biochemistry 56:1836-1840
Rienzo, Matthew; Rocchi, Angela R; Threatt, Stephanie D et al. (2016) Perturbation of Critical Prolines in Gloeobacter violaceus Ligand-gated Ion Channel (GLIC) Supports Conserved Gating Motions among Cys-loop Receptors. J Biol Chem 291:6272-80
Nichols, Weston A; Henderson, Brandon J; Marotta, Christopher B et al. (2016) Mutation Linked to Autosomal Dominant Nocturnal Frontal Lobe Epilepsy Reduces Low-Sensitivity ?4?2, and Increases ?5?4?2, Nicotinic Receptor Surface Expression. PLoS One 11:e0158032
Davis, Matthew R; Dougherty, Dennis A (2015) Cation-? interactions: computational analyses of the aromatic box motif and the fluorination strategy for experimental evaluation. Phys Chem Chem Phys 17:29262-70
Henderson, Brandon J; Lester, Henry A (2015) Inside-out neuropharmacology of nicotinic drugs. Neuropharmacology 96:178-93
Marotta, Christopher B; Lester, Henry A; Dougherty, Dennis A (2015) An Unaltered Orthosteric Site and a Network of Long-Range Allosteric Interactions for PNU-120596 in ?7 Nicotinic Acetylcholine Receptors. Chem Biol 22:1063-73
Post, Michael R; Limapichat, Walrati; Lester, Henry A et al. (2015) Heterologous expression and nonsense suppression provide insights into agonist behavior at ?6?2 nicotinic acetylcholine receptors. Neuropharmacology 97:376-82
Miles, Timothy F; Lester, Henry A; Dougherty, Dennis A (2015) Allosteric activation of the 5-HT3AB receptor by mCPBG. Neuropharmacology 91:103-8

Showing the most recent 10 out of 110 publications