Abstract

This is a revised application for renewal of a research project aiming to determine how motor experience during early life influences the development of the cortical motor representations and corticospinal connections.
The first aim i s to study the relationships between the normal morphological and functional development of CS axon terminal arbors.
The second aim i s to determine the roles of motor experience and neural activity during early life in shaping the functional and morphological development of corticospinal terminal arbors and of cortical motor representations.
The third aim i s to determine the effects of impaired limb use or cortical activity blockade during development on kinematics and dynamic control of skilled movements. By understanding experiential factors influencing early development of the corticospinal system and skilled movements, the investigators hope to devise more targeted interventional and rehabilitation strategies.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
2R01NS036835-04A1
Application #
6292181
Study Section
Special Emphasis Panel (ZRG1-IFCN-5 (01))
Program Officer
Spinella, Giovanna M
Project Start
1997-07-01
Project End
2004-12-31
Budget Start
2001-01-15
Budget End
2001-12-31
Support Year
4
Fiscal Year
2001
Total Cost
$300,296
Indirect Cost

  Institution

Name
New York State Psychiatric Institute
Department
Type
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032

  Publications

Williams, Preston T J A; Jiang, Yu-Qiu; Martin, John H (2017) Motor system plasticity after unilateral injury in the developing brain. Dev Med Child Neurol 59:1224-1229
Serradj, Najet; Paixão, Sónia; Sobocki, Tomasz et al. (2014) EphA4-mediated ipsilateral corticospinal tract misprojections are necessary for bilateral voluntary movements but not bilateral stereotypic locomotion. J Neurosci 34:5211-21
Williams, Preston T J A; Kim, Sangsoo; Martin, John H (2014) Postnatal maturation of the red nucleus motor map depends on rubrospinal connections with forelimb motor pools. J Neurosci 34:4432-41
Friel, Kathleen M; Chakrabarty, Samit; Martin, John H (2013) Pathophysiological mechanisms of impaired limb use and repair strategies for motor systems after unilateral injury of the developing brain. Dev Med Child Neurol 55 Suppl 4:27-31
Paixão, Sónia; Balijepalli, Aarathi; Serradj, Najet et al. (2013) EphrinB3/EphA4-mediated guidance of ascending and descending spinal tracts. Neuron 80:1407-20
Friel, Kathleen; Chakrabarty, Samit; Kuo, Hsing-Ching et al. (2012) Using motor behavior during an early critical period to restore skilled limb movement after damage to the corticospinal system during development. J Neurosci 32:9265-76
Martin, John H (2012) Systems neurobiology of restorative neurology and future directions for repair of the damaged motor systems. Clin Neurol Neurosurg 114:515-23
Chakrabarty, Samit; Martin, John H (2011) Co-development of proprioceptive afferents and the corticospinal tract within the cervical spinal cord. Eur J Neurosci 34:682-94
Martin, John H; Chakrabarty, Samit; Friel, Kathleen M (2011) Harnessing activity-dependent plasticity to repair the damaged corticospinal tract in an animal model of cerebral palsy. Dev Med Child Neurol 53 Suppl 4:9-13
Chakrabarty, Samit; Martin, John (2011) Postnatal refinement of proprioceptive afferents in the cat cervical spinal cord. Eur J Neurosci 33:1656-66

Showing the most recent 10 out of 24 publications