Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
3R01NS037277-01S1
Application #
2853374
Study Section
AIDS and Related Research Study Section 7 (ARRG)
Program Officer
Kerza-Kwiatecki, a P
Project Start
1998-02-01
Project End
2002-01-31
Budget Start
1998-02-01
Budget End
1999-01-31
Support Year
1
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
149617367
City
Boston
State
MA
Country
United States
Zip Code
02215
Mefford, Megan E; Gorry, Paul R; Kunstman, Kevin et al. (2008) Bioinformatic prediction programs underestimate the frequency of CXCR4 usage by R5X4 HIV type 1 in brain and other tissues. AIDS Res Hum Retroviruses 24:1215-20
Agopian, Kristin; Wei, Bangdong L; Garcia, J Victor et al. (2007) CD4 and MHC-I downregulation are conserved in primary HIV-1 Nef alleles from brain and lymphoid tissues, but Pak2 activation is highly variable. Virology 358:119-35
Sterjovski, Jasminka; Churchill, Melissa J; Ellett, Anne et al. (2007) Asn 362 in gp120 contributes to enhanced fusogenicity by CCR5-restricted HIV-1 envelope glycoprotein variants from patients with AIDS. Retrovirology 4:89
Thomas, Elaine R; Dunfee, Rebecca L; Stanton, Jennifer et al. (2007) High frequency of defective vpu compared with tat and rev genes in brain from patients with HIV type 1-associated dementia. AIDS Res Hum Retroviruses 23:575-80
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Gray, Lachlan; Churchill, Melissa J; Sterjovski, Jasminka et al. (2007) Phenotype and envelope gene diversity of nef-deleted HIV-1 isolated from long-term survivors infected from a single source. Virol J 4:75
Dunfee, Rebecca L; Thomas, Elaine R; Wang, Jianbin et al. (2007) Loss of the N-linked glycosylation site at position 386 in the HIV envelope V4 region enhances macrophage tropism and is associated with dementia. Virology 367:222-34
Gorry, Paul R; Dunfee, Rebecca L; Mefford, Megan E et al. (2007) Changes in the V3 region of gp120 contribute to unusually broad coreceptor usage of an HIV-1 isolate from a CCR5 Delta32 heterozygote. Virology 362:163-78
Thomas, Elaine R; Dunfee, Rebecca L; Stanton, Jennifer et al. (2007) Macrophage entry mediated by HIV Envs from brain and lymphoid tissues is determined by the capacity to use low CD4 levels and overall efficiency of fusion. Virology 360:105-19
Wang, Jianbin; Gabuzda, Dana (2006) Reconstitution of human immunodeficiency virus-induced neurodegeneration using isolated populations of human neurons, astrocytes, and microglia and neuroprotection mediated by insulin-like growth factors. J Neurovirol 12:472-91

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