Abstract

Public Health Relevance

The proposed studies will investigate how growth factors induce directed migration of neural precursors. These investigations of polarity and migration will lead to approaches for restricting the extensive migration of malignant brain tumor cells that arise from neural precursors. In addition these studies will explain why errors in migration predispose to defects in brain circuitry in neuropsychiatric disorders such as dyslexia and autism.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS037757-11
Application #
7895097
Study Section
Neurogenesis and Cell Fate Study Section (NCF)
Program Officer
Mamounas, Laura
Project Start
1998-09-30
Project End
2012-06-30
Budget Start
2010-07-01
Budget End
2012-06-30
Support Year
11
Fiscal Year
2010
Total Cost
$409,058
Indirect Cost

  Institution

Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
076580745
City
Boston
State
MA
Country
United States
Zip Code
02215

  Publications

Zhou, Pengcheng; Alfaro, Jose; Chang, Eun Hyuk et al. (2011) Numb links extracellular cues to intracellular polarity machinery to promote chemotaxis. Dev Cell 20:610-22
Gruber-Olipitz, Mariella; Segal, Rosalind A (2009) Live or let die: CCM2 provides the link. Neuron 63:559-60
Chan, Jennifer A; Balasubramanian, Srividya; Witt, Rochelle M et al. (2009) Proteoglycan interactions with Sonic Hedgehog specify mitogenic responses. Nat Neurosci 12:409-17
Zhou, Pengcheng; Porcionatto, Marimelia; Pilapil, Mariecel et al. (2007) Polarized signaling endosomes coordinate BDNF-induced chemotaxis of cerebellar precursors. Neuron 55:53-68
Choi, Yoojin; Borghesani, Paul R; Chan, Jennifer A et al. (2005) Migration from a mitogenic niche promotes cell-cycle exit. J Neurosci 25:10437-45
Carter, Alexandre R; Berry, Erin M; Segal, Rosalind A (2003) Regional expression of p75NTR contributes to neurotrophin regulation of cerebellar patterning. Mol Cell Neurosci 22:1-13
Kim, John Y H; Nelson, Aaron L; Algon, Sibel A et al. (2003) Medulloblastoma tumorigenesis diverges from cerebellar granule cell differentiation in patched heterozygous mice. Dev Biol 263:50-66
Segal, Rosalind A (2003) Selectivity in neurotrophin signaling: theme and variations. Annu Rev Neurosci 26:299-330
Rubin, Joshua B; Segal, Rosalind A (2003) Growth, survival and migration: the Trk to cancer. Cancer Treat Res 115:1-18
Borghesani, Paul R; Peyrin, Jean Michel; Klein, Robyn et al. (2002) BDNF stimulates migration of cerebellar granule cells. Development 129:1435-42

Showing the most recent 10 out of 15 publications