Abstract

? We are requesting supplemental funding for the four remaining years of our recently renewed R01 to allow us to follow a very promising new area of research. The overall goal of our funded research is to better analyze acute MRI data to better predict tissue and clinical outcome in patients with acute ischemic stroke. We now believe, based on preliminary data presented in this request, that the inclusion of molecular biomarkers - particularly genetic and plasma markers - can improve our predictive models of tissue and clinical outcome. We seek support to incorporate imaging and genetic information together in a way to better understand both the phenotypic expression of genetic variability and the impact that molecular markers may have in the prediction of stroke outcome. We will specifically investigate a genetic biomarker, the apolipoprotein E allele, and a serum biomarker, matrix metalloproteinase 9, for their ability to improve our predictive models. Incorporating genetic and imaging information together could greatly strengthen the relevance and immediacy of each. ? ?

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
3R01NS038477-07S1
Application #
6925296
Study Section
Medical Imaging Study Section (MEDI)
Program Officer
Conwit, Robin
Project Start
1999-04-23
Project End
2009-03-31
Budget Start
2005-04-01
Budget End
2006-03-31
Support Year
7
Fiscal Year
2005
Total Cost
$118,500
Indirect Cost

  Institution

Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199

  Publications

Ay, Ilknur; Sorensen, A Gregory; Ay, Hakan (2011) Vagus nerve stimulation reduces infarct size in rat focal cerebral ischemia: an unlikely role for cerebral blood flow. Brain Res 1392:110-5
Uppal, Ritika; Catana, Ciprian; Ay, Ilknur et al. (2011) Bimodal thrombus imaging: simultaneous PET/MR imaging with a fibrin-targeted dual PET/MR probe--feasibility study in rat model. Radiology 258:812-20
Singhal, Aneesh B; Hajj-Ali, Rula A; Topcuoglu, Mehmet A et al. (2011) Reversible cerebral vasoconstriction syndromes: analysis of 139 cases. Arch Neurol 68:1005-12
Arsava, E Murat; Furie, Karen L; Schwamm, Lee H et al. (2011) Prediction of early stroke risk in transient symptoms with infarction: relevance to the new tissue-based definition. Stroke 42:2186-90
Gokcay, Figen; Arsava, Ethem Murat; Baykaner, Tuna et al. (2011) Age-dependent susceptibility to infarct growth in women. Stroke 42:947-51
Arsava, E M; Bayrlee, A; Vangel, M et al. (2011) Severity of leukoaraiosis determines clinical phenotype after brain infarction. Neurology 77:55-61
Sorensen, A Gregory; Ay, Hakan (2011) Transient ischemic attack: definition, diagnosis, and risk stratification. Neuroimaging Clin N Am 21:303-13, x
Wu, Ona; Schwamm, Lee H; Sorensen, A Gregory (2011) Imaging stroke patients with unclear onset times. Neuroimaging Clin N Am 21:327-44, xi
Uppal, Ritika; Ay, Ilknur; Dai, Guangping et al. (2010) Molecular MRI of intracranial thrombus in a rat ischemic stroke model. Stroke 41:1271-7
Schellinger, P D; Bryan, R N; Caplan, L R et al. (2010) Evidence-based guideline: The role of diffusion and perfusion MRI for the diagnosis of acute ischemic stroke: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology 75:177-85

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