This is a renewal application for the highly successful Brain Attack Surveillance in Corpus Christi (BASIC) Project. BASIC is the only ongoing stroke surveillance project focusing on Mexican Americans. Mexican Americans are the largest segment of the Hispanic American population, the United States'largest minority group. Since the inception of this project in January 2000, we have assembled a cohort of over 4,992 cerebrovascular disease patients for whom we are able to follow for recurrent cerebrovascular events as well as mortality. This gives us tremendous power to detect associations with biological and social risk factors for stroke, important to Mexican Americans as well as the broader United States population. We have demonstrated increased stroke incidence and recurrence in Mexican Americans. Stroke severity and ischemic stroke subtypes are similar between Mexican Americans and non-Hispanic whites. Mortality following stroke appears to be less in Mexican Americans. In the next five years we are positioned to delineate trends in stroke rates, and to explore the potential reasons for the increased stroke burden in Mexican Americans, as well as their improved survival. This information will be critically important to all populations to reduce the devastation of stroke. We will continue to make important observations useful for planning delivery of stroke care in communities. For the first time we will investigate functional and cognitive outcome following stroke in Mexican Americans and non-Hispanic whites. We will now also study the role of health care quality and medication compliance on stroke outcomes. We will collect blood on all stroke patients useful for genetic studies by our group and others, and we have initiated stroke surveillance in a similar community within Mexico that will serve as a great basis for comparison to the Corpus Christi population. BASIC has been a very prolific study with more than 27 original peer-reviewed publications in the last four years alone. Indeed, this study is just beginning to provide the rich epidemiologic and clinical data that are necessary to control the epidemic of cerebrovascular disease in Mexican Americans. We know that the next five years will allow us to make contributions that will be directly useful for interventions to reduce health disparities, prevent stroke and improve stroke outcomes in all populations.

Public Health Relevance

This is a competitive renewal for the Brain Attack Surveillance in Corpus Christi (BASIC) project. This highly successful community-based stroke epidemiology project seeks to understand the health disparity for stroke among Mexican Americans and non Hispanic whites in Corpus Christi, Texas. This accomplished through observational epidemiology and interviews of patients. No intervention is contained in the study.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Research Project (R01)
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Study Section
Neurological, Aging and Musculoskeletal Epidemiology (NAME)
Program Officer
Waddy, Salina P
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University of Michigan Ann Arbor
Schools of Medicine
Ann Arbor
United States
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Lisabeth, Lynda D; Scheer, Richard V; Li, Chengwei et al. (2018) Intracerebral hemorrhage and sleep-disordered breathing. Sleep Med 46:114-116
McDermott, Mollie; Brown, Devin L; Li, Chengwei et al. (2018) Sex differences in sleep-disordered breathing after stroke: results from the BASIC project. Sleep Med 43:54-59
Lisabeth, Lynda D; Baek, Jonggyu; Morgenstern, Lewis B et al. (2018) Prognosis of Midlife Stroke. J Stroke Cerebrovasc Dis 27:1153-1159
Gall, Seana; Phan, Hoang; Madsen, Tracy E et al. (2018) Focused Update of Sex Differences in Patient Reported Outcome Measures After Stroke. Stroke 49:531-535
Lisabeth, Lynda D; Horn, Susan D; Ifejika, Nneka L et al. (2018) The difficulty of studying race-ethnic stroke rehabilitation disparities in a community. Top Stroke Rehabil 25:393-396
Li, Chengwei; Baek, Jonggyu; Sanchez, Brisa N et al. (2018) Temporal trends in age at ischemic stroke onset by ethnicity. Ann Epidemiol 28:686-690.e2
Dong, Liming; Sánchez, Brisa N; Skolarus, Lesli E et al. (2018) Ethnic Differences in Prevalence of Post-stroke Depression. Circ Cardiovasc Qual Outcomes 11:e004222
Lisabeth, Lynda D; Sánchez, Brisa N; Chervin, Ronald D et al. (2017) High prevalence of poststroke sleep-disordered breathing in Mexican Americans. Sleep Med 33:97-102
Wing, Jeffrey J; Sánchez, Brisa N; Adar, Sara D et al. (2017) Synergism of Short-Term Air Pollution Exposures and Neighborhood Disadvantage on Initial Stroke Severity. Stroke 48:3126-3129
Wing, Jeffrey J; Adar, Sara D; Sánchez, Brisa N et al. (2017) Short-term exposures to ambient air pollution and risk of recurrent ischemic stroke. Environ Res 152:304-307

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