Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
3R01NS039258-05S1
Application #
6796973
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Oliver, Eugene J
Project Start
1999-04-15
Project End
2008-03-31
Budget Start
2003-04-01
Budget End
2004-03-31
Support Year
5
Fiscal Year
2003
Total Cost
$84,000
Indirect Cost
Name
Weill Medical College of Cornell University
Department
Neurology
Type
Schools of Medicine
DUNS #
060217502
City
New York
State
NY
Country
United States
Zip Code
10065
Chandra, Abhishek; Johri, Ashu; Beal, M Flint (2014) Prospects for neuroprotective therapies in prodromal Huntington's disease. Mov Disord 29:285-93
Chaturvedi, Rajnish Kumar; Hennessey, Thomas; Johri, Ashu et al. (2012) Transducer of regulated CREB-binding proteins (TORCs) transcription and function is impaired in Huntington's disease. Hum Mol Genet 21:3474-88
Johri, Ashu; Starkov, Anatoly A; Chandra, Abhishek et al. (2011) Truncated peroxisome proliferator-activated receptor-? coactivator 1? splice variant is severely altered in Huntington's disease. Neurodegener Dis 8:496-503
Yang, Lichuan; Beal, M Flint (2011) Determination of neurotransmitter levels in models of Parkinson's disease by HPLC-ECD. Methods Mol Biol 793:401-15
Zhang, S F; Hennessey, T; Yang, L et al. (2011) Impaired brain creatine kinase activity in Huntington's disease. Neurodegener Dis 8:194-201
Stack, Cliona; Ho, Daniel; Wille, Elizabeth et al. (2010) Triterpenoids CDDO-ethyl amide and CDDO-trifluoroethyl amide improve the behavioral phenotype and brain pathology in a transgenic mouse model of Huntington's disease. Free Radic Biol Med 49:147-58
Johri, Ashu; Beal, M Flint (2010) Hunting-ton for new proteases: MMPs as the new target? Neuron 67:171-3
Chaturvedi, Rajnish K; Calingasan, Noel Y; Yang, Lichuan et al. (2010) Impairment of PGC-1alpha expression, neuropathology and hepatic steatosis in a transgenic mouse model of Huntington's disease following chronic energy deprivation. Hum Mol Genet 19:3190-205
Ho, Daniel J; Calingasan, Noel Y; Wille, Elizabeth et al. (2010) Resveratrol protects against peripheral deficits in a mouse model of Huntington's disease. Exp Neurol 225:74-84
Yang, Lichuan; Calingasan, Noel Y; Thomas, Bobby et al. (2009) Neuroprotective effects of the triterpenoid, CDDO methyl amide, a potent inducer of Nrf2-mediated transcription. PLoS One 4:e5757

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