Role of Matrix Metalloproteinases in Spinal Cord Injury

Noble, Linda J.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Neurological Disorders and Stroke (NINDS)
• Type: Research Project (R01)
• Project #: 5R01NS039278-03
• Application #: 6394254
• Study Section: Special Emphasis Panel (ZRG1-BDCN-2 (01))
• Program Officer: Kleitman, Naomi
• Project Start: 1999-09-30
• Project End: 2003-07-31
• Budget Start: 2001-08-01
• Budget End: 2002-07-31
• Support Year: 3
• Fiscal Year: 2001
• Total Cost: $235,215

Institution

• Name: University of California San Francisco
• Department: Neurosurgery
• Type: Schools of Medicine
• DUNS #: 073133571
• City: San Francisco
• State: CA
• Country: United States
• Zip Code: 94143

Publications

Trivedi, Alpa; Zhang, Haoqian; Ekeledo, Adanma et al. (2016) Deficiency in matrix metalloproteinase-2 results in long-term vascular instability and regression in the injured mouse spinal cord. Exp Neurol 284:50-62

Levine, Jonathan M; Cohen, Noah D; Heller, Michael et al. (2014) Efficacy of a metalloproteinase inhibitor in spinal cord injured dogs. PLoS One 9:e96408

Phillips, Joanna J; Huillard, Emmanuelle; Robinson, Aaron E et al. (2012) Heparan sulfate sulfatase SULF2 regulates PDGFR? signaling and growth in human and mouse malignant glioma. J Clin Invest 122:911-22

Zhang, Haoqian; Chang, Mayland; Hansen, Christopher N et al. (2011) Role of matrix metalloproteinases and therapeutic benefits of their inhibition in spinal cord injury. Neurotherapeutics 8:206-20

Levine, Jonathan M; Levine, Gwendolyn J; Porter, Brian F et al. (2011) Naturally occurring disk herniation in dogs: an opportunity for pre-clinical spinal cord injury research. J Neurotrauma 28:675-88

Lee, Sang Mi; Rosen, Steven; Weinstein, Philip et al. (2011) Prevention of both neutrophil and monocyte recruitment promotes recovery after spinal cord injury. J Neurotrauma 28:1893-907

Zhang, Haoqian; Trivedi, Alpa; Lee, Jung-Uek et al. (2011) Matrix metalloproteinase-9 and stromal cell-derived factor-1 act synergistically to support migration of blood-borne monocytes into the injured spinal cord. J Neurosci 31:15894-903

Pozniak, Christine D; Langseth, Abraham J; Dijkgraaf, Gerrit J P et al. (2010) Sox10 directs neural stem cells toward the oligodendrocyte lineage by decreasing Suppressor of Fused expression. Proc Natl Acad Sci U S A 107:21795-800

Zhang, Haoqian; Adwanikar, Hita; Werb, Zena et al. (2010) Matrix metalloproteinases and neurotrauma: evolving roles in injury and reparative processes. Neuroscientist 16:156-70

Hsu, Jung-Yu C; Bourguignon, Lilly Y W; Adams, Christen M et al. (2008) Matrix metalloproteinase-9 facilitates glial scar formation in the injured spinal cord. J Neurosci 28:13467-77