This project will develop a novel control system to automatically regulate posture and actively restore balance to users of neuroprostheses for standing after spinal cord injury. Current standing neuroprostheses utilizing functional neuromuscular stimulation (FNS) only provide support and prevent collapse by stiffening the lower extremities through continuous supramaximal stimulation of the knee, hip and trunk extensors. They include no mechanism to actively maintain balance or compensate for disturbances, and rely on the upper extremities to make the postural corrections required to remain balanced in the upright position. This project will address the shortcomings of currently available FNS standing systems by developing a sensor-driven """"""""artificial vestibular system"""""""" that will actively monitor posture, anticipate perturbations to balance and automatically modulate stimulation to keep the user upright. This will be accomplished by combining innovative feed-forward, feedback and adaptive control techniques at multiple joints and in three dimensions. A small number of simple, but information-rich, body-mounted sensors will capture the actions of the torso as well as the lower extremities. Dynamic stability will be achieved by using accelerations of the trunk to predict and rapidly respond to disturbances in a feed-forward manner. Static stability will be achieved by regulating center of pressure within the base of support using feedback control, and adaptive algorithms will be applied to compensate for fatigue. A model-based approach to controller development will be adopted that relies on computer simulation, optimization and performance verification prior human testing. This new control system should reduce reliance on the upper extremities while standing with FNS, thus advancing the goal of providing neuroprosthesis users with freer use of their hands to manipulate objects in the environment by automatically maintaining balance in the presence of intrinsic and extrinsic disturbances.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS040547-02
Application #
6394532
Study Section
Geriatrics and Rehabilitation Medicine (GRM)
Program Officer
Heetderks, William J
Project Start
2000-09-21
Project End
2003-07-31
Budget Start
2001-08-01
Budget End
2002-07-31
Support Year
2
Fiscal Year
2001
Total Cost
$282,400
Indirect Cost
Name
Case Western Reserve University
Department
Orthopedics
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Audu, Musa L; Odle, Brooke M; Triolo, Ronald J (2018) Control of standing balance at leaning postures with functional neuromuscular stimulation following spinal cord injury. Med Biol Eng Comput 56:317-330
Triolo, Ronald J; Bailey, Stephanie Nogan; Foglyano, Kevin M et al. (2018) Long-Term Performance and User Satisfaction With Implanted Neuroprostheses for Upright Mobility After Paraplegia: 2- to 14-Year Follow-Up. Arch Phys Med Rehabil 99:289-298
Hunt, Alexander J; Odle, Brooke M; Lombardo, Lisa M et al. (2017) Reactive stepping with functional neuromuscular stimulation in response to forward-directed perturbations. J Neuroeng Rehabil 14:54
Nataraj, Raviraj; Audu, Musa L; Triolo, Ronald J (2017) Restoring standing capabilities with feedback control of functional neuromuscular stimulation following spinal cord injury. Med Eng Phys 42:13-25
Nataraj, Raviraj; Audu, Musa L; Triolo, Ronald J (2016) Simulating the restoration of standing balance at leaning postures with functional neuromuscular stimulation following spinal cord injury. Med Biol Eng Comput 54:163-76
Audu, Musa L; Gartman, Steven J; Nataraj, Raviraj et al. (2014) Posture-dependent control of stimulation in standing neuroprosthesis: simulation feasibility study. J Rehabil Res Dev 51:481-96
Nataraj, Raviraj; Audu, Musa L; Triolo, Ronald J (2014) Modified Newton-Raphson method to tune feedback gains of control system for standing by functional neuromuscular stimulation following spinal cord injury. Appl Bionics Biomech 11:169-174
Nataraj, Raviraj; Audu, Musa L; Triolo, Ronald J (2013) Center of mass acceleration feedback control of standing balance by functional neuromuscular stimulation against external postural perturbations. IEEE Trans Biomed Eng 60:10-9
Nataraj, Raviraj; Audu, Musa L; Kirsch, Robert F et al. (2012) Trunk acceleration for neuroprosthetic control of standing: a pilot study. J Appl Biomech 28:85-92
Nataraj, Raviraj; Audu, Musa L; Triolo, Ronald J (2012) Center of mass acceleration feedback control of functional neuromuscular stimulation for standing in presence of internal postural perturbations. J Rehabil Res Dev 49:889-911

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