Abstract

Although many axon guidance molecules have been identified, the signaling and cell biological mechanisms leading to directed axon growth are still poorly understood. Building on our progress, we will ask in-depth questions about novel signaling and cell biological mechanisms of axon guidance. Specifically, we will use Frizzled3 phosphorylation and trafficking as a tool to solve how signaling asymmetry is generated in the growth cone and the cell biological mechanisms involved in turning. We will also use genetic mosaic approaches to study axon-axon interactions to address the unanswered question of how a group of axons pathfind together.

Public Health Relevance

This study proposes to discover novel signaling and cell biological mechanisms of axon guidance in development of functional circuits. These studies will provide basic scientific basis for therapeutic designs for neural circuit repair.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS047484-13
Application #
9040007
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Riddle, Robert D
Project Start
2003-12-01
Project End
2018-04-30
Budget Start
2016-05-01
Budget End
2017-04-30
Support Year
13
Fiscal Year
2016
Total Cost
Indirect Cost

  Institution

Name
University of California San Diego
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093

  Publications

Huang, Ming; Cheng, Gen; Tan, Han et al. (2017) Capsaicin protects cortical neurons against ischemia/reperfusion injury via down-regulating NMDA receptors. Exp Neurol 295:66-76
Ponsetto, Joseph L; Bezryadina, Anna; Wei, Feifei et al. (2017) Experimental Demonstration of Localized Plasmonic Structured Illumination Microscopy. ACS Nano 11:5344-5350
Thakar, Sonal; Wang, Liqing; Yu, Ting et al. (2017) Evidence for opposing roles of Celsr3 and Vangl2 in glutamatergic synapse formation. Proc Natl Acad Sci U S A 114:E610-E618
Onishi, Keisuke; Zou, Yimin (2017) Sonic Hedgehog switches on Wnt/planar cell polarity signaling in commissural axon growth cones by reducing levels of Shisa2. Elife 6:
Li, Zezhi; Wang, Zuowei; Zhang, Chen et al. (2017) Reduced ENA78 levels as novel biomarker for major depressive disorder and venlafaxine efficiency: Result from a prospective longitudinal study. Psychoneuroendocrinology 81:113-121
Hollis 2nd, Edmund R; Ishiko, Nao; Yu, Ting et al. (2016) Ryk controls remapping of motor cortex during functional recovery after spinal cord injury. Nat Neurosci 19:697-705
Hollis 2nd, Edmund R; Ishiko, Nao; Pessian, Maysam et al. (2015) Remodelling of spared proprioceptive circuit involving a small number of neurons supports functional recovery. Nat Commun 6:6079
Hollis 2nd, Edmund R; Ishiko, Nao; Tolentino, Kristine et al. (2015) A novel and robust conditioning lesion induced by ethidium bromide. Exp Neurol 265:30-9
Lemmon, Vance P; Ferguson, Adam R; Popovich, Phillip G et al. (2014) Minimum information about a spinal cord injury experiment: a proposed reporting standard for spinal cord injury experiments. J Neurotrauma 31:1354-61
Zou, Yimin; Salinas, Patricia (2014) Introduction: Wnt signaling mechanisms in development and disease. Dev Neurobiol 74:757-8

Showing the most recent 10 out of 27 publications