The goal of this competing continuation is to complete a 30-year longitudinal study of a stable population of cotton textile workers in Shanghai, China. This cohort has been evaluated for cotton dust and endotoxin exposure as well as pulmonary effects since 1981. This unique study remains the longest and largest prospective cohort study of textile workers to date, with an unusually high (> 80%) participation rate and a large proportion of non-smokers. To date, this study has enabled us to report dust and endotoxin-related pulmonary effects, including new insights on the effect of exposure cessation and the role of some candidate genes related to endotoxin exposure. However, scientific uncertainties remain. Specifically, for over five decades, controversy continues as to whether emphysema or chronic bronchitis is the basis of the observed airway obstruction. Prior autopsy studies on small numbers of deceased workers have been conflicting. With the advent of improved high resolution computed tomography (HRCT) since 2002, as well as validated automated techniques to quantify the degree of emphysema and airways disease present in an individual, this proposal represents an unusual opportunity to apply this innovative technology to this unique and well characterized cohort of cotton and silk textile workers. We propose to extend follow-up in our study to a 30 year sampling so that we may explore in vivo several data-intensive strategies to elucidate the biological processes involved in dust and endotoxin-related lung disease.
Our first aim i s to assess the relationship between respiratory health status and long term exposure to cotton dust and endotoxin, as well as evaluate the effect of removal of exposure in retired workers;
our second aim i s to perform HRCT of the chest in study cohort volunteers, both exposed and unexposed to dust/endotoxin and with/without respiratory disease to identify the structural basis for the observed lung impairment. Finally, in the third aim we will test additional candidate gene polymorphisms that may modulate the development of dust and endotoxin-related airways disease. Continued study of this unique cohort by our experienced group of investigators using a comprehensive and innovative approach will help us identify key biological basis underlying the development of occupationally-related airways disease from organic dust and endotoxin exposure. The study addresses respiratory disease in the health outcome cross-sectors portion of the NIOSH extramural program portfolio.

Public Health Relevance

The goal of this competing continuation is to complete a 30-year longitudinal study of a stable population of cotton textile workers with the goals of determining the precise nature of the airways disease in workers exposed to vegetable dust and the associated bacterial endotoxins. We will also assess potential improvement in lung function after removal from exposure, as well as susceptibility factors for occupational airways disease among this population.

National Institute of Health (NIH)
National Institute for Occupational Safety and Health (NIOSH)
Research Project (R01)
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Safety and Occupational Health Study Section (SOH)
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Dearwent, Steve
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Harvard University
Public Health & Prev Medicine
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Lai, Peggy S; Hang, Jing-Qing; Zhang, Feng-Ying et al. (2016) Imaging Phenotype of Occupational Endotoxin-Related Lung Function Decline. Environ Health Perspect 124:1436-42
Ahasic, Amy M; Tejera, Paula; Wei, Yongyue et al. (2015) Predictors of Circulating Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor-Binding Protein-3 in Critical Illness. Crit Care Med 43:2651-9
Lai, Peggy S; Hang, Jing-Qing; Valeri, Linda et al. (2015) Endotoxin and gender modify lung function recovery after occupational organic dust exposure: a 30-year study. Occup Environ Med 72:546-552
Lai, Peggy S; Hang, Jing-Qing; Zhang, Feng-Ying et al. (2014) Gender differences in the effect of occupational endotoxin exposure on impaired lung function and death: the Shanghai Textile Worker Study. Occup Environ Med 71:118-125
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Fang, S C; Mehta, A J; Hang, J Q et al. (2013) Cotton dust, endotoxin and cancer mortality among the Shanghai textile workers cohort: a 30-year analysis. Occup Environ Med 70:722-9
Lai, Peggy S; Christiani, David C (2013) Long-term respiratory health effects in textile workers. Curr Opin Pulm Med 19:152-7
Zhang, Ruyang; Zhao, Yang; Chu, Minjie et al. (2013) A large scale gene-centric association study of lung function in newly-hired female cotton textile workers with endotoxin exposure. PLoS One 8:e59035
Lai, Peggy S; Fresco, Jennifer M; Pinilla, Miguel A et al. (2012) Chronic endotoxin exposure produces airflow obstruction and lung dendritic cell expansion. Am J Respir Cell Mol Biol 47:209-17
Shi, Jing; Hang, Jing-Qing; Mehta, Amar J et al. (2010) Long-term effects of work cessation on respiratory health of textile workers: a 25-year follow-up study. Am J Respir Crit Care Med 182:200-6

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