Age-related cognitive decline may affect functional independence. Visual search tasks can predict accidents in the elderly. However, most visual search studies in aging rely on brief stimulus presentations and speeded manual responses. It is therefore unclear whether such conditions may reflect the cognitive, sensory, or motor processes involved in other real-life spatial search tasks, particularly where stimuli are visible for extended periods and speeded responses are not required. Cancellation tests usually require manually marking multiple targets in a display while ignoring distractors. Speeded responses are not strictly required, and stimuli may be visible indefinitely. Such tests can be used to assess speed of processing and spatial attention. Cancellation tests are usually given to brain injured subjects. However, recent studies indicate they also may be sensitive to search processes in aging.
The aim of this study is to determine whether new methods of cancellation assessment can improve the test's sensitivity to age-related changes in spatial search. The cancellation test will be presented on an interactive touchscreen display. Subjects will touch all targets in random-array cancellation tests with a stylus. Depending on the test, targets when touched will either (1) be marked, (2) disappear, or (3) show no visible change at all. These modifications will model different outcomes of visuomanual exploration of the environment. The display device will calculate (1) number of targets touched, (2) speed of processing, (3) organization of search (through total pathway intersections), and (4) perseverated target contacts. Through assessing whether changes in test format affect these measures, we will determine whether the cancellation test's sensitivity to age-related changes in spatial search may be improved. The findings will provide normative data for future research to determine whether cancellation tests may be sensitive to functional decline in aging and neurologic disorders.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Small Research Grants (R03)
Project #
1R03AG021256-01
Application #
6546345
Study Section
Special Emphasis Panel (ZAG1-ZIJ-5 (M1))
Program Officer
Wagster, Molly V
Project Start
2002-09-01
Project End
2004-08-31
Budget Start
2002-09-01
Budget End
2004-08-31
Support Year
1
Fiscal Year
2002
Total Cost
$72,479
Indirect Cost
Name
University of Alabama Birmingham
Department
Physical Medicine & Rehab
Type
Schools of Medicine
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Woods, Adam J; Mark, Victor W; Pitts, Anthony C et al. (2011) Pervasive cognitive impairment in acute rehabilitation inpatients without brain injury. PM R 3:426-32; quiz 432
Woods, Adam J; Mennemeier, Mark; Garcia-Rill, Edgar et al. (2006) Bias in magnitude estimation following left hemisphere injury. Neuropsychologia 44:1406-12
Mark, Victor W; Oberheu, Anne Marie; Henderson, Cathy et al. (2005) Ballism after stroke responds to standard physical therapeutic interventions. Arch Phys Med Rehabil 86:1226-33
Mark, V W; Woods, A J; Ball, K K et al. (2004) Disorganized search on cancellation is not a consequence of neglect. Neurology 63:78-84