The Einstein Aging Study (EAS) program project (NIH NIA: P01 AG03949) is a longitudinal study of the natural history of aging and the onset of dementia in a diverse community-based sample in Bronx, New York. We propose to archive the EAS dataset at the National Archive of Computerized Data on Aging (NACDA), in order to make this rich and unique data set available for public use. This will facilitate investigations into th aging process that are beyond the scope of our funded studies. The EAS has systematically recruited and followed a community-based, multi-racial cohort (n=2014, ages >=70) for more than 20 years. EAS participants have been comprehensively characterized via extensive evaluations at baseline and annually thereafter, with an average follow-up time of 4.0 years (range, 1-17 years). Data from the EAS have demonstrated strong links among cognitive, locomotor, and mortality outcomes in the elderly and have been used to identify novel biological and psychosocial risk factors that contribute to these outcomes. The EAS cohort is broadly representative of the elderly population of the Bronx, one of the most demographically diverse counties in the United States. Since 2003, the EAS has complied with the NIH data sharing mandate. Many of the data sharing requests has been part of multiple NIH collaborative studies. To date, however, the analytic focus of these pooled analyses has been limited to the discreet subset of EAS variables related to Alzheimer's disease and cognitive decline, with the result that much of the extensive EAS data resource remains underexploited. The proposed Data Archiving project will permit us to build on the extant database in two essential ways: (1) to capture and preserve the wide range of variables assessed in our cohort during the years 1993-2003 (prior to the date of the Mandatory Data Sharing Policy put forth by the NIH (October 1, 2003)). This includes harmonizing previously un-archived data with the current EAS database;and (2) to expand the database to include the host of behavioral, biological and psychosocial measures, not part of the primary EAS program project, that have been funded from pilot projects, foundation grants, and affiliated NIH R01s. Creating and documenting new summary measures and standard formats will be part of the process. The central aims of this proposal are to archive and preserve an expanded EAS data base in order to facilitate efficient and cost effective use of the extensive scientific resources from our long-standing and well-characterized cohort. The proposed collaboration with NACDA will ensure our capacity for wide-spread dissemination of high quality data to the national and international aging research communities.
The aim of this proposal is to facilitate efficient and cost effective sharing of data from the Einstein Aging Study (EAS), a long-term well characterized cohort, through archiving in collaboration with the National Archive of Computerized Data on Aging (NACDA). Archiving this data base will expand the utility of this valuable database by increasing the availability of the high quality EAS data to the broader aging research community.
|Jiang, Julie M; Seng, Elizabeth K; Zimmerman, Molly E et al. (2017) Evaluation of the Reliability, Validity, and Predictive Validity of the Subscales of the Perceived Stress Scale in Older Adults. J Alzheimers Dis 59:987-996|
|Sundermann, Erin E; Katz, Mindy J; Lipton, Richard B (2017) Sex Differences in the Relationship between Depressive Symptoms and Risk of Amnestic Mild Cognitive Impairment. Am J Geriatr Psychiatry 25:13-22|
|Graham, Eileen K; Rutsohn, Joshua P; Turiano, Nicholas A et al. (2017) Personality Predicts Mortality Risk: An Integrative Data Analysis of 15 International Longitudinal Studies. J Res Pers 70:174-186|
|Ezzati, Ali; Wang, Cuiling; Lipton, Richard B et al. (2017) Association Between Vascular Pathology and Rate of Cognitive Decline Independent of Alzheimer's Disease Pathology. J Am Geriatr Soc 65:1836-1841|
|Ezzati, Ali; Rundek, Tatjana; Verghese, Joe et al. (2017) Transcranial Doppler and Lower Extremity Function in Older Adults: Einstein Aging Study. J Am Geriatr Soc 65:2659-2664|
|Jiang, Julie M; Seng, Elizabeth K; Zimmerman, Molly E et al. (2017) Positively worded subscale score of the Perceived Stress Scale is associated with cognitive domain function. J Behav Brain Sci 7:311-324|
|Eslami, Vahid; Zimmerman, Molly E; Grewal, Trishdeep et al. (2016) Pain grade and sleep disturbance in older adults: evaluation the role of pain, and stress for depressed and non-depressed individuals. Int J Geriatr Psychiatry 31:450-7|
|Ezzati, Ali; Katz, Mindy J; Zammit, Andrea R et al. (2016) Differential association of left and right hippocampal volumes with verbal episodic and spatial memory in older adults. Neuropsychologia 93:380-385|
|Sundermann, Erin Elizabeth; Wang, Cuiling; Katz, Mindy et al. (2016) Cholesteryl ester transfer protein genotype modifies the effect of apolipoprotein ?4 on memory decline in older adults. Neurobiol Aging 41:200.e7-200.e12|
|Katz, Mindy J; Derby, Carol A; Wang, Cuiling et al. (2016) Influence of Perceived Stress on Incident Amnestic Mild Cognitive Impairment: Results From the Einstein Aging Study. Alzheimer Dis Assoc Disord 30:93-8|
Showing the most recent 10 out of 13 publications