Abstract

Over the past five years it has become apparent that endogenous pyrogen, leukocyte endogenous mediator, and lymphocyte activating factor are all similar, if not identical, proteins now referred to as interleukin 1. As a result, it is apparent that investigators from many seemingly unrelated disciplines have a common interest in understanding better the biology of interleukin 1. The objective of the proposed conference is: 1. to gather researchers actively investigating various aspects of interleukin 1 to discuss the multiple physiologic, metabolic and immunologic actions of this exciting protein, 2. to describe the mechanisms involved in interleukin 1 production, release, and action, 3. to attempt to determine how the various activities attributable to interleukin 1 integrate the host's response to injury, infection, and inflammation, 4. to attempt to elucidate the role interleukin 1 plays in intercellular communication in health, 5. to attempt to identify the potential therapeutic value of: a. modulation of endogenous interleukin 1 concentration, or b. exogenous administration of interleukin 1, and 6. to assess how an understanding of interleukin 1 production and function can be used to develop drugs that modulate specific and nonspecific immunity.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Conference (R13)
Project #
1R13AI021632-01
Application #
3433420
Study Section
Transplantation and Immunology Committee (TIC)
Project Start
1985-02-01
Project End
1986-01-31
Budget Start
1985-02-01
Budget End
1986-01-31
Support Year
1
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of Michigan Ann Arbor
Department
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109

  Publications

Feng, Ningguo; Lawton, Jeffrey A; Gilbert, Joana et al. (2002) Inhibition of rotavirus replication by a non-neutralizing, rotavirus VP6-specific IgA mAb. J Clin Invest 109:1203-13
Youngman, Kenneth R; Franco, Manuel A; Kuklin, Nelly A et al. (2002) Correlation of tissue distribution, developmental phenotype, and intestinal homing receptor expression of antigen-specific B cells during the murine anti-rotavirus immune response. J Immunol 168:2173-81
Gilber, J M; Feng, N; Patton, J T et al. (2001) Rotavirus assembly - interaction of surface protein VP7 with middle layer protein VP6. Arch Virol 146:1155-71
Cook, D N; Prosser, D M; Forster, R et al. (2000) CCR6 mediates dendritic cell localization, lymphocyte homeostasis, and immune responses in mucosal tissue. Immunity 12:495-503
Franco, M A; Greenberg, H B (1999) Immunity to rotavirus infection in mice. J Infect Dis 179 Suppl 3:S466-9
Gilbert, J M; Greenberg, H B (1998) Cleavage of rhesus rotavirus VP4 after arginine 247 is essential for rotavirus-like particle-induced fusion from without. J Virol 72:5323-7
Franco, M A; Tin, C; Greenberg, H B (1997) CD8+ T cells can mediate almost complete short-term and partial long-term immunity to rotavirus in mice. J Virol 71:4165-70
Feng, N; Vo, P T; Chung, D et al. (1997) Heterotypic protection following oral immunization with live heterologous rotaviruses in a mouse model. J Infect Dis 175:330-41
Ishida, S I; Feng, N; Gilbert, J M et al. (1997) Immune responses to individual rotavirus proteins following heterologous and homologous rotavirus infection in mice. J Infect Dis 175:1317-23
Tang, B; Gilbert, J M; Matsui, S M et al. (1997) Comparison of the rotavirus gene 6 from different species by sequence analysis and localization of subgroup-specific epitopes using site-directed mutagenesis. Virology 237:89-96

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