The International Primary CNS Lymphoma Collaborative Group (IPCG), formed at the 8th International Conference on Malignant Lymphomas in Lugano, Switzerland in June 2002, meets on a biannual basis and has attracted both a multidisciplinary and international membership. The primary objective of the IPCG is to advance the biological understanding, diagnosis and treatment of patients with primary central nervous system lymphoma (PCNSL). Topics of prior meetings have included: 1) Consensus guidelines for PCNSL clinical trials;2) Primary T-cell lymphoma of the nervous system;3) Low-grade CNS lymphoma. The goals of each thematic meeting are to review the preclinical and clinical science relevant to each topic;to produce multidisciplinary, collaborative research focused on each selected topic and, when appropriate, to disseminate scientific guidelines and methods for use by PCNSL researchers. Peer-reviewed publications have resulted from prior meetings including a vision statement for the IPCG;consensus guidelines for clinical trials in the PCNSL patient population;and a summary of the largest series of primary T-cell lymphomas of the nervous system published to date. Treatment-related neurotoxicity in PCNSL patients is the next major prospective IPCG project and will be the subject of the next scientific meeting. Attendance at IPCG meetings includes scientists, neuropsychologists and physicians from multiple specialties involved in every aspect of PCNSL clinical care and research. In addition, distinguished scientists and clinical investigators have been invited to the thematic sessions. Although the group has existed for only 3 years it have fostered international collaboration across multiple disciplines on an unprecedented scale and has had an impact on PCNSL research and clinical care.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Conference (R13)
Project #
5R13CA124293-05
Application #
7908725
Study Section
Special Emphasis Panel (ZCA1-GRB-T (M1))
Program Officer
Wu, Roy S
Project Start
2006-09-01
Project End
2011-08-31
Budget Start
2010-09-01
Budget End
2011-08-31
Support Year
5
Fiscal Year
2010
Total Cost
$5,000
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199
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Batchelor, Tracy T; Reardon, David A; de Groot, John F et al. (2014) Antiangiogenic therapy for glioblastoma: current status and future prospects. Clin Cancer Res 20:5612-9
Flannick, Jason; Thorleifsson, Gudmar; Beer, Nicola L et al. (2014) Loss-of-function mutations in SLC30A8 protect against type 2 diabetes. Nat Genet 46:357-63
Ponzoni, M; Issa, S; Batchelor, T T et al. (2014) Beyond high-dose methotrexate and brain radiotherapy: novel targets and agents for primary CNS lymphoma. Ann Oncol 25:316-22
Taylor, Jennie W; Flanagan, Eoin P; O'Neill, Brian P et al. (2013) Primary leptomeningeal lymphoma: International Primary CNS Lymphoma Collaborative Group report. Neurology 81:1690-6
Ferreri, Andrés J M; Zucca, Emanuele; Armitage, James et al. (2013) Ten years of international primary CNS lymphoma collaborative group studies. J Clin Oncol 31:3444-5
Abla, Oussama; Weitzman, Sheila; Blay, Jean-Yves et al. (2011) Primary CNS lymphoma in children and adolescents: a descriptive analysis from the International Primary CNS Lymphoma Collaborative Group (IPCG). Clin Cancer Res 17:346-52
Patrij, Katrin; Reiser, Marcel; Wätzel, Luise et al. (2011) Isolated central nervous system relapse of systemic lymphoma (SCNSL): clinical features and outcome of a retrospective analysis. Ger Med Sci 9:Doc11
Chan, Chi-Chao; Rubenstein, James L; Coupland, Sarah E et al. (2011) Primary vitreoretinal lymphoma: a report from an International Primary Central Nervous System Lymphoma Collaborative Group symposium. Oncologist 16:1589-99

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