? The six members of the GATA transcription factor family have now been shown to be vital for numerous ? distinct developmental events and for the differentiation of multiple organs and cell lineages, including the fat, blood, cardiovascular, nervous, skin, liver and urogenital systems. This is a very active field of research that relates directly to the general inquiry of regulation of gene expression during development. This field is also of immediate medical importance, since it has been shown that a GATA factor is responsible for the increased incidence in one form of leukemia among Downs' syndrome patients (mutations in GATA1) and mutation of a different GATA factor (GATA3) leads to human HDR syndrome, a haploinsufficient disorder resulting in hearing loss, kidney malformation and parathyroid endocrine dysfunction. Even more recently, mutations in GATA4 have been shown to be associated with congenital heart disease. We believe that these highly focused conferences on the GATA factors held every three years have played a seminal role in illuminating numerous developmental pathways of immediate importance in understanding human disease, and we anticipate that this conference will similarly lead to new collaborations and an even deeper understanding of how ineffective gene ? regulation by these proteins lead to human disorders. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Conference (R13)
Project #
1R13DK079654-01
Application #
7331528
Study Section
Special Emphasis Panel (ZDK1-GRB-S (M3))
Program Officer
Wright, Daniel G
Project Start
2007-07-15
Project End
2008-06-30
Budget Start
2007-07-15
Budget End
2008-06-30
Support Year
1
Fiscal Year
2007
Total Cost
$10,000
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109