This grant application investigates the nature of anti-viral host immune responses against papillomaviruses, specifically cottontail rabbit papillomavirus ( CRPV). Specifically, the PI describes experiments to investigate whether CRPV infection leads to a modulation of expression of CD40 in rabbit keratinocytes. This T-lymphocyte co-stimulatory molecules has recently been detected in human keratinocytes. Therefore the PI hypothesizes that modulation of its expression by papillomavirus infection could alter host immune responses. The three aims of this grant are 1) to clone the rabbit homologue of CD40, 2) to establish whether rabbit CD40 is expressed in rabbit keratinocytes, and 3) to determine whether its expression is present in tissue infected with CRPV and whether this expression differs in those lesions that represent persistent infections, or progressing versus regressing lesions.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Academic Research Enhancement Awards (AREA) (R15)
Project #
1R15AI043033-01
Application #
2617916
Study Section
Virology Study Section (VR)
Project Start
1998-06-01
Project End
2003-05-31
Budget Start
1998-06-01
Budget End
2003-05-31
Support Year
1
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Eastern Michigan University
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
623664018
City
Ypsilanti
State
MI
Country
United States
Zip Code
48197