Although cytotoxic nucleoside analogues and transition metals were among the first chemotherapeutic agents to be introduced for the medical treatment of cancer, the availability of a combination of both classes of compounds remains scarce, mostly due to synthetic challenges. We propose here a new synthetic methodology for the synthesis of bicyclic modified nucleosides that can be converted into their organometallics. Pursuing the leading structures of hexacarbonyl dicobalt complexes that exhibit activity against human mammary tumor cells, we will synthesize a library of new metallonucleosides and conduct structure-activity relationship studies.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Academic Research Enhancement Awards (AREA) (R15)
Project #
1R15CA111329-01
Application #
6848642
Study Section
Medicinal Chemistry Study Section (MCHA)
Program Officer
Lees, Robert G
Project Start
2005-06-01
Project End
2009-05-31
Budget Start
2005-06-01
Budget End
2009-05-31
Support Year
1
Fiscal Year
2005
Total Cost
$216,750
Indirect Cost
Name
Oakland University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
041808262
City
Rochester
State
MI
Country
United States
Zip Code
48309
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