Abstract

The studies described in this grant are designed to investigate the interrelationships between the mechanisms regulating growth and sexual maturation.
The specific aim i s to investigate the effects of growth hormone (GH) deprivation during various stages of development of the young animal on puberty. GH deprivation will be accomplished by passively immunizing the animals with antiserum raised against growth hormone-releasing hormone (GHRH). This methodology is ideal in that it represents a non- invasive functional lesion of the neuroendocrine axis controlling GH secretion and growth which is highly specific and yet reversible. The studies represent a portion of ongoing long-term studies designed to characterize the physiological relationship between GHRH and GH as it relates to normal growth and development.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Academic Research Enhancement Awards (AREA) (R15)
Project #
1R15DK040078-01
Application #
3437850
Study Section
Reproductive Biology Study Section (REB)
Project Start
1988-05-01
Project End
1991-04-30
Budget Start
1988-05-01
Budget End
1991-04-30
Support Year
1
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
University of Wisconsin Milwaukee
Department
Type
Sch Allied Health Professions
DUNS #
City
Milwaukee
State
WI
Country
United States
Zip Code
53201