/Relevance The goal of this project is to develop a 3D vascular tissue model to investigate the early cellular mechanisms associated with atherosclerosis, as an improvement over the existing 2D models. Such a model will make it possible to study solute concentration gradients and their effect on the cells within the model. Successful completion of this project will result in a 3D vascular tissue model that can be used to both develop and test therapeutics for atherosclerosis and to prevent further complications like heart disease (the leading cause of death in the U.S.).
| Fennell, Christopher J; Ghousifam, Neda; Haseleu, Jennifer M et al. (2018) Computational Signaling Protein Dynamics and Geometric Mass Relations in Biomolecular Diffusion. J Phys Chem B 122:5599-5609 |
| Ghousifam, Neda; Mortazavian, Hamid; Bhowmick, Rudra et al. (2017) A three-dimensional in vitro model to demonstrate the haptotactic effect of monocyte chemoattractant protein-1 on atherosclerosis-associated monocyte migration. Int J Biol Macromol 97:141-147 |
| Leemasawatdigul, Krisada; Gappa-Fahlenkamp, Heather (2012) Development of a mathematical model to describe the transport of monocyte chemoattractant protein-1 through a three-dimensional collagen matrix. Cardiovasc Pathol 21:219-28 |
| Leemasawatdigul, Krisada; Gappa-Fahlenkamp, Heather (2011) Effect of storage conditions on the stability of recombinant human MCP-1/CCL2. Biologicals 39:29-32 |
