The proposed study would examine the relationships between hormonal factors, inflammatory mediators, related gene variants and adult-onset asthma in the Nurses' Health Study (NHS). The NHS is an ongoing prospective cohort study involving 121,700 women age 30 to 55 in 1976. Since 1988, all participants have been asked about a new """"""""physician diagnosis of asthma"""""""" and a new """"""""physician diagnosis of chronic obstructive pulmonary disease (COPD)."""""""" The primary aim will be to examine the relationship of endogenous female reproductive hormones and risk of newly diagnosed asthma. The main hypotheses are listed here as questions: 1) Do elevated endogenous levels of free (bioavailable) estradiol and other estrogens prospectively increase risk of physician diagnosed asthma in postmenopausal women? 2) Do elevated estrogen-associated inflammatory markers, such as C-reactive protein and interleukin-6, prospectively predict adult-onset asthma? 3) Do estrogen receptor and metabolism gene variants, such as the low activity allele of catechol-O-methyl transferase (COMT), increase risk of adult-onset asthma among postmenopausal women? We propose to study the above hypotheses in nested case-control studies in the cohort of postmenopausal women in the NHS. In 1989, 23,099 blood samples were obtained from postmenopausal women. Follow-up of these participants through 2000 revealed approximately 300 reports of new physician diagnoses of diagnosed asthma that required use of an asthma medication. Use of this existing cohort with previously collected blood samples will provide relatively quick and very cost-effective answers to longstanding uncertainty about the effect of female reproductive hormones on asthma.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Exploratory/Developmental Grants (R21)
Project #
1R21AI052338-01A1
Application #
6630090
Study Section
Special Emphasis Panel (ZRG1-SNEM-5 (02))
Program Officer
Plaut, Marshall
Project Start
2003-06-15
Project End
2005-05-31
Budget Start
2003-06-15
Budget End
2005-05-31
Support Year
1
Fiscal Year
2003
Total Cost
$303,606
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
02115
Varraso, Raphaëlle; Chiuve, Stephanie E; Fung, Teresa T et al. (2015) Alternate Healthy Eating Index 2010 and risk of chronic obstructive pulmonary disease among US women and men: prospective study. BMJ 350:h286
Varraso, Raphaëlle; Barr, R Graham; Willett, Walter C et al. (2015) Fish intake and risk of chronic obstructive pulmonary disease in 2 large US cohorts. Am J Clin Nutr 101:354-61
Garcia-Aymerich, Judith; Varraso, Raphaëlle; Danaei, Goodarz et al. (2014) Incidence of adult-onset asthma after hypothetical interventions on body mass index and physical activity: an application of the parametric g-formula. Am J Epidemiol 179:20-6
Le Moual, Nicole; Varraso, Raphaëlle; Zock, Jan Paul et al. (2013) Are operating room nurses at higher risk of severe persistent asthma? The Nurses' Health Study. J Occup Environ Med 55:973-7
Liao, Michael M; Ginde, Adit A; Clark, Sunday et al. (2010) Salmeterol use and risk of hospitalization among emergency department patients with acute asthma. Ann Allergy Asthma Immunol 104:478-84
Varraso, Raphaëlle; Willett, Walter C; Camargo Jr, Carlos A (2010) Prospective study of dietary fiber and risk of chronic obstructive pulmonary disease among US women and men. Am J Epidemiol 171:776-84
Garcia-Aymerich, Judith; Varraso, Raphaëlle; Antó, Josep M et al. (2009) Prospective study of physical activity and risk of asthma exacerbations in older women. Am J Respir Crit Care Med 179:999-1003
Jacobson, Brian C; Somers, Samuel C; Fuchs, Charles S et al. (2006) Body-mass index and symptoms of gastroesophageal reflux in women. N Engl J Med 354:2340-8