If you close your eyes you can still image the world around you, and, with your eyes closed point to the spatial location of objects in the world. Patients with lesions of the parietal cortex have deficits in visual memory, and cannot locate objects in the world with their eyes closed. We have discovered that neurons in the lateral intraparietal area, a region in the parietal lobe, maintain a memory of objects in the environment across several trials. When a subject makes a saccade that brings the spatial location of a remembered object into the receptive field of a neuron, the neuron responds as if the object were still there, although with a longer latency and lesser (although still significant) response.
The aims of this proposal are to determine the brain areas upon which this environmental memory depends. We will examine the role of three candidates: the frontal eye field, the parahippocampal gyrus, and the eye position region of primary somatosensory cortex.

Public Health Relevance

Normal humans have a detailed visual memory of their environment. With their eyes closed they can point to objects in their environment, or describe familiar places. Patients with lesions of the parietal lobe cannot do this, and the absence of visual memory for action interferes with their rehabilitative potential. This proposal seeks to understand the basic neurophysiology responsible for this environmental memory, in order better to be able to plan rehabilitative strategies.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Exploratory/Developmental Grants (R21)
Project #
1R21EY020631-01A1
Application #
7991108
Study Section
Central Visual Processing Study Section (CVP)
Program Officer
Steinmetz, Michael A
Project Start
2010-08-01
Project End
2011-07-31
Budget Start
2010-08-01
Budget End
2011-07-31
Support Year
1
Fiscal Year
2010
Total Cost
$241,500
Indirect Cost
Name
Columbia University (N.Y.)
Department
Neurosciences
Type
Schools of Medicine
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Semework, Mulugeta; Steenrod, Sara C; Goldberg, Michael E (2018) A spatial memory signal shows that the parietal cortex has access to a craniotopic representation of space. Elife 7:
Steenrod, Sara C; Phillips, Matthew H; Goldberg, Michael E (2013) The lateral intraparietal area codes the location of saccade targets and not the dimension of the saccades that will be made to acquire them. J Neurophysiol 109:2596-605
Xu, Benjamin Y; Karachi, Carine; Goldberg, Michael E (2012) The postsaccadic unreliability of gain fields renders it unlikely that the motor system can use them to calculate target position in space. Neuron 76:1201-9
Ipata, Anna E; Gee, Angela L; Goldberg, Michael E (2012) Feature attention evokes task-specific pattern selectivity in V4 neurons. Proc Natl Acad Sci U S A 109:16778-85
Xu, Yixing; Wang, Xiaolan; Peck, Christopher et al. (2011) The time course of the tonic oculomotor proprioceptive signal in area 3a of somatosensory cortex. J Neurophysiol 106:71-7
Gee, Angela L; Ipata, Anna E; Goldberg, Michael E (2010) Activity in V4 reflects the direction, but not the latency, of saccades during visual search. J Neurophysiol 104:2187-93
Bisley, James W; Goldberg, Michael E (2010) Attention, intention, and priority in the parietal lobe. Annu Rev Neurosci 33:1-21