State-of-the art neural recording technologies for in vivo applications can record simultaneously from a few hundred microelectrode recording sites. These recording sites are passive electrodes wired to read-out circuitry outside the brain. The number of wires entering the brain is equal to number of recording sites. This one-to-one relationship between recording sites and access wires is a major obstacle to obtaining high-density recordings from large areas of the brain, preventing technology scaling to many thousands of electrodes. We propose to break the conventional N-wire, N-electrode array architecture using graphene bio-FET sensors to enable frequency-based multiplexing and shared sensor wires. Specifically, the goal of this project is to demonstrate a neural recording platform that has N recording sites accessed by 2?? wires. Such a technology would enable recording from 22,500 recording sites with only 300 wires entering the brain. A key component of our proposed architecture is active graphene electrodes that allow signal mixing at the recording site, and a frequency modulation scheme that allows sharing each interface wire among many active electrodes. The proposed project includes both design and nanofabrication of the flexible sensor array, as well as development and implementation of a custom integrated circuit architecture for the multiplex recording interface. By fabrication of atomically thin sensors on flexible substrates, we will provide dense, conformal neural sensor arrays for surface recordings.
We aim to develop a scalable platform that can simultaneously achieve high signal count, high spatial resolution, and sufficient temporal precision to infer functional interactions between neurons.

Public Health Relevance

State-of-the art neural recording technologies for in vivo applications can record simultaneously from a few hundred electrodes, but this will need to increase to a several thousand electrodes to support emerging research and medical applications. We propose to create a flexible, dense electrode array using graphene sensors for measuring neural activity on the brain surface with high resolution and high speed. Our approach will enable better research tools and may improve technological capabilities for diagnosing and treating a variety of neurological diseases.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Exploratory/Developmental Grants (R21)
Project #
1R21EY030007-01
Application #
9693438
Study Section
Special Emphasis Panel (ZNS1)
Program Officer
Flanders, Martha C
Project Start
2019-06-01
Project End
2021-05-31
Budget Start
2019-06-01
Budget End
2021-05-31
Support Year
1
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Oregon State University
Department
Engineering (All Types)
Type
Biomed Engr/Col Engr/Engr Sta
DUNS #
053599908
City
Corvallis
State
OR
Country
United States
Zip Code
97331