Despite advances in OCT technology over the past two decades, retinal OCT systems are still limited by their speed. This has many consequences on how OCT is used. Perhaps most significantly, current speeds restrict the imaged field to a fraction of the total retinal area. This prevents diseases of the peripheral retina from being imaged in routine OCT scans. Two recent technologies in the field of OCT and photonics may offer a technological path toward much higher-speed retinal OCT. The first is a circular-ranging OCT method that employs optical-domain compression to avoid acquisition barriers to high-speed imaging. The second in Lithium- Niobate-on-insulator (LNOI) photonic integrated filters, which can be leveraged to create high-performance and low-cost CR-OCT laser sources. In this work, we propose studies to evaluate the feasibility of a CR-OCT/LNOI platform that is 100-fold faster than commercially available retinal OCT systems.
In Aim 1, we will fabricate a wavelength-stepped optical filter based on LNOI circuits.
In Aim 2, we will use this filter to build a high- performance mode-locked CR-OCT laser source. If successful, this work will define a technical strategy toward comprehensive retinal imaging by OCT.

Public Health Relevance

Despite advances in OCT technology over the past two decades, clinical applications continue to demand further gains in imaging speed. New advances in the fields of OCT and photonics create opportunities to dramatically accelerate retinal OCT imaging. This work leverages these advances to build the foundation for a new ultra high-speed retinal OCT technology.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Exploratory/Developmental Grants (R21)
Project #
1R21EY031895-01
Application #
10048393
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Shen, Grace L
Project Start
2020-09-01
Project End
2022-08-31
Budget Start
2020-09-01
Budget End
2021-08-31
Support Year
1
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02114