Modern antiretroviral treatments delay disease progression and death and create the possibility for HIV+ individuals to live near-normal life-spans. However, the treatments only partial restore immune function, have unknown long-term (>10 year) toxicities, and likely only partially reverse damage done by the virus prior to the initiation of therapy. The critical question that arises is how will clinicians maximize treatment success and minimize treatment and disease-associated long term toxicities? To answer this question, investigators need access to clinical outcome information that is tightly linked to biologic specimens and socio-biologic data to enable translational research. The CFAR Network of Integrated Clinical Systems (CNICS) project is a new resource that can contribute substantially to the contemporary HIV research agenda. Established in 2002 and funded as an R24 research platform in 2006, CNICS is a clinic-based research network that reflects the outcomes of clinical decisions and management options used in the care of HIV infected individuals at 8 CFAR sites: UAB, U Washington, UCSF, UCSD, Case Western Reserve, Fenway Community Clinic (Brown/Harvard), U North Carolina, and Johns Hopkins. The CNICS project supports a database that serves as a central repository of verified and quality-controlled data from the electronic medical records (EMRs) at each site. The clinical data is linked to patient reported outcome obtained at regular intervals, geospatial data, and to biologic specimens stored in repositories and readily available for use in translational research projects. The mission of CNICS is to provide access to the specimen and data repository to any investigator who submits an approved concept proposal. In this fashion, CNICS is a 'peer-reviewed open access'research platform available to investigators worldwide.
The specific aims for this competitive renewal of CNICS are to: 1: Expand the original CNICS research platform;2: Provide direct access to the expanded CNICS research platform to as many investigators as feasible;and 3: Establish a Mentoring Program that targets early and mid-career investigators engaged in multidisciplinary HIV-focused research.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Resource-Related Research Projects (R24)
Project #
2R24AI067039-06
Application #
8142519
Study Section
Special Emphasis Panel (ZAI1-EC-A (J1))
Program Officer
Mckaig, Rosemary G
Project Start
2005-07-01
Project End
2016-08-30
Budget Start
2011-09-01
Budget End
2012-08-31
Support Year
6
Fiscal Year
2011
Total Cost
$3,513,072
Indirect Cost
Name
University of Alabama Birmingham
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Merlin, Jessica S; Westfall, Andrew O; Long, Dustin et al. (2018) A Randomized Pilot Trial of a Novel Behavioral Intervention for Chronic Pain Tailored to Individuals with HIV. AIDS Behav 22:2733-2742
Buchanan, Ashley L; Hudgens, Michael G; Cole, Stephen R et al. (2018) Generalizing Evidence from Randomized Trials using Inverse Probability of Sampling Weights. J R Stat Soc Ser A Stat Soc 181:1193-1209
Lesko, Catherine R; Buchanan, Ashley L; Westreich, Daniel et al. (2018) The Authors Respond. Epidemiology 29:e14-e15
Lee, Hana; Wu, Xiaotian K; Genberg, Becky L et al. (2018) Beyond binary retention in HIV care: predictors of the dynamic processes of patient engagement, disengagement, and re-entry into care in a US clinical cohort. AIDS 32:2217-2225
Edwards, Jessie K; Cole, Stephen R; Moore, Richard D et al. (2018) Sensitivity Analyses for Misclassification of Cause of Death in the Parametric G-Formula. Am J Epidemiol :
Lesko, Catherine R; Edwards, Jessie K; Cole, Stephen R et al. (2018) When to Censor? Am J Epidemiol 187:623-632
Merlin, Jessica S; Long, Dustin; Becker, William C et al. (2018) Brief Report: The Association of Chronic Pain and Long-Term Opioid Therapy With HIV Treatment Outcomes. J Acquir Immune Defic Syndr 79:77-82
Adland, Emily; Hill, Matilda; Lavandier, Nora et al. (2018) Differential Immunodominance Hierarchy of CD8+ T-Cell Responses in HLA-B*27:05- and -B*27:02-Mediated Control of HIV-1 Infection. J Virol 92:
Altekruse, Sean F; Shiels, Meredith S; Modur, Sharada P et al. (2018) Cancer burden attributable to cigarette smoking among HIV-infected people in North America. AIDS 32:513-521
DiPrete, Bethany L; Pence, Brian W; Bengtson, Angela M et al. (2018) The Depression Treatment Cascade: Disparities by Alcohol Use, Drug Use, and Panic Symptoms Among Patients in Routine HIV Care in the United States. AIDS Behav :

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