Cochrane is an international nonprofit organization with the mission to improve health-related decisions by preparing, maintaining and promoting the accessibility of systematic reviews. The Complementary Medicine Field is the Cochrane group that is focused on supporting the production and dissemination of Cochrane systematic reviews of complementary and integrative medicine therapies. The Field is based within and sponsored by the Center for Integrative Medicine at the University of Maryland, under the direction of Brian Berman, who co-founded the Field in 1996. Over the past 20 years, the Field has been supported through an R24 grant from NCCIH. The Field has used this R24 grant to significantly advance NCCIH's objective to develop and disseminate the ?current best evidence? on complementary and integrative health to support decision-making on the part of patients, health care practitioners, policy makers, and research administrators. However, many questions about the usefulness and safety of complementary therapies do not yet have relevant, up-to-date, and actionable answers, and there is a need to continue the rigorous development, effective dissemination, and incorporation into practice of high quality, objective information on complementary and integrative therapies. To further expand the Complementary Medicine Field as a resource for research, this proposed renewal of our R24 grant has the following 4 specific aims: 1) Improve and increase the database of controlled trials of complementary medicine interventions; 2) Increase the number of high quality, high priority, up-to-date systematic reviews in complementary medicine; 3) Increase the relevance, usability and accessibility of the Complementary Medicine Field resources and research evidence to patient, clinical, and research stakeholders; and 4) Promote international collaboration by contributing to the Cochrane organization. Since its founding, the Field has displayed a high level of productivity in our trial database development, systematic review production, and methodological work. The Field will continue its productivity in these areas and increase effective prioritization and knowledge translation of its products, supported by the Cochrane research and dissemination infrastructure and the worldwide complementary medicine network developed by the Field over the previous 20 years.

Public Health Relevance

RELEVANCE Systematic reviews of controlled trials are considered the gold standard for evaluating the effectiveness of healthcare interventions, including complementary and integrative therapies (CAM). The availability of relevant controlled trials is crucial for the conduct of these systematic reviews, and Cochrane has been in the vanguard of controlled trial database development and systematic review methods since 1992.1-3 This grant will support the Cochrane Complementary Medicine Field in developing and expanding our database of CAM controlled trials and in preparing and disseminating high priority, high quality CAM systematic reviews.

National Institute of Health (NIH)
National Center for Complementary & Alternative Medicine (NCCAM)
Resource-Related Research Projects (R24)
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Special Emphasis Panel (ZAT1)
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Clark, David
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University of Maryland Baltimore
Family Medicine
Schools of Medicine
United States
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Wu, Ruo-Han; Feng, Shuo; Han, Mei et al. (2018) Yinzhihuang oral liquid combined with phototherapy for neonatal jaundice: a systematic review and meta-analysis of randomized clinical trials. BMC Complement Altern Med 18:228
Dudics, Steven; Langan, David; Meka, Rakeshchandra R et al. (2018) Natural Products for the Treatment of Autoimmune Arthritis: Their Mechanisms of Action, Targeted Delivery, and Interplay with the Host Microbiome. Int J Mol Sci 19:
Wieland, L Susan; Santesso, Nancy (2018) A Summary of a Cochrane Review: Acupuncture or acupressure for induction of labour. Eur J Integr Med 17:141-142
Vinceti, Marco; Filippini, Tommaso; Del Giovane, Cinzia et al. (2018) Selenium for preventing cancer. Cochrane Database Syst Rev 1:CD005195
Parker, Elizabeth A; Roy, Tina; D'Adamo, Christopher R et al. (2018) Probiotics and gastrointestinal conditions: An overview of evidence from the Cochrane Collaboration. Nutrition 45:125-134.e11
Choi, Gwang-Ho; Wieland, L Susan; Lee, Hyangsook et al. (2018) Acupuncture and related interventions for the treatment of symptoms associated with carpal tunnel syndrome. Cochrane Database Syst Rev 12:CD011215
Manheimer, Eric; Cheng, Ke; Wieland, L Susan et al. (2018) Acupuncture for hip osteoarthritis. Cochrane Database Syst Rev 5:CD013010
Wieland, L Susan; Santesso, Nancy (2017) A Summary of a Cochrane Review: Yoga treatment for chronic non-specific low back pain. Eur J Integr Med 11:39-40
Zhou, Fen; Liang, Ning; Maier, Manfred et al. (2017) Sanfu acupoint herbal patching for stable asthma: A systematic review and meta-analysis of randomised controlled trials. Complement Ther Med 30:40-53
Wieland, L Susan; Berman, Brian M; Altman, Douglas G et al. (2017) Rating of Included Trials on the Efficacy-Effectiveness Spectrum: development of a new tool for systematic reviews. J Clin Epidemiol 84:95-104

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