Abstract

The present application proposes Alcohol, Drug Abuse and Mental Health (ADM) research projects that will enhance the ability of our institution to conduct ADM research. The objectives of this proposal are: 1. To strengthen the institutional infrastructure. 2. To enhance the capability of individual faculty members to perform ADM research. 3. To involve outstanding students in research in order to encourage them to pursue careers in ADM research. The three-dimensional structure and electronic character of (-)-cocaine and (-)-norcocaine will be determined. The effect of commonly prescribed drugs on the hepatotoxicity of cocaine will be investigated in a mouse model. An endogenous ligand of the central benzodiazepine receptor will be identified. The effect of this endogenous ligand on GABA-gated chloride uptake into synaptoneurosomes will be determined. New analogs of anti-AIDS drugs will be synthesized to prevent and treat the mental health effects of AIDS. The bioavailability, metabolic, and blood-brain distribution of these new drugs will be determined. Novel anti-Pneumocystis carinii drugs with less hepatotoxicity will be synthesized to enable improved drug therapy of alcoholic AIDS patients with liver damage. Pharmacokinetic interactions between anti-AIDS and anti-Pneumocystis carinii drugs will be studied. Finally, the effects of chronic alcohol consumption on the appearance of Pneumocystis carinii in a rat model will be determined.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Resource-Related Research Projects (R24)
Project #
5R24DA007970-02
Application #
3450348
Study Section
Drug Abuse Biomedical Research Review Committee (DABR)
Project Start
1992-08-14
Project End
1995-07-31
Budget Start
1993-08-01
Budget End
1994-07-31
Support Year
2
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
Xavier University of Louisiana
Department
Type
Schools of Pharmacy
DUNS #
020857876
City
New Orleans
State
LA
Country
United States
Zip Code
70125

  Publications

Mayence, Annie; Vanden Eynde, Jean Jacques; Krogstad, Fran M et al. (2004) Parallel solution-phase synthesis of conformationally restricted congeners of pentamidine and evaluation of their antiplasmodial activities. J Med Chem 47:2700-5
Mayence, Annie; Vanden Eynde, Jean Jacques; LeCour Jr, Louis et al. (2004) Piperazine-linked bisbenzamidines: a novel class of antileishmanial agents. Eur J Med Chem 39:547-53
Homayoun, P; Mandal, T; Landry, D et al. (2003) Controlled release of anti-cocaine catalytic antibody from biodegradable polymer microspheres. J Pharm Pharmacol 55:933-8
Donkor, Isaac O; Huang, Tien L; Tao, Bin et al. (2003) Trypanocidal activity of conformationally restricted pentamidine congeners. J Med Chem 46:1041-8
Mandal, Tarun K; Bostanian, Levon A; Graves, Richard A et al. (2002) Poly(D,L-lactide-co-glycolide) encapsulated poly(vinyl alcohol) hydrogel as a drug delivery system. Pharm Res 19:1713-9
Zhang, Qiang; Ma, Peng; Iszard, Marcus et al. (2002) In vitro metabolism of R(+)-[2,3-dihydro-5-methyl-3-[(morpholinyl)methyl]pyrrolo [1,2,3-de]1,4-benzoxazinyl]-(1-naphthalenyl) methanone mesylate, a cannabinoid receptor agonist. Drug Metab Dispos 30:1077-86
Brakta, Mohamed; Murthy, Devangachinta; Ellis, L'Ouverture et al. (2002) 9-[(Hydroxymethyl)phenyl]adenines: new aryladenine substrates of adenosine deaminase. Bioorg Med Chem Lett 12:1489-92
Huang, T L; Tao, B; Quarshie, Y et al. (2001) N,N'-bis[4-(N-alkylamidino)phenyl]homopiperazines as anti-Pneumocystis carinii agents. Bioorg Med Chem Lett 11:2679-81
Mandal, T K; Bostanian, L A (2000) Effect of peptide loading and surfactant concentration on the characteristics of physically crosslinked hydrogel. Pharm Dev Technol 5:555-60
Mandal, T K (2000) Swelling-controlled release system for the vaginal delivery of miconazole. Eur J Pharm Biopharm 50:337-43

Showing the most recent 10 out of 17 publications