Although smoking cessation efforts by NIDA and others have been successful, millions of Americans continue to smoke. Additionally, our laboratories have found important results on the metabolic effects of nicotine, including findings that nicotine plus a high fat diet (HFD) leads to hepatic and muscle steatosis. We have also used a large database to show that secondhand smoke is associated with both diabetes and obesity. This has led us to develop the theme of the Charles R. Drew University of Medicine and Science (CDU) Diversity-Promoting Institution Drug Abuse Research Program (DIDARP) to be Metabolic Effects of Nicotine: it Matters. Our training theme will continue to be Research Teams of the Future that is based on the NIH roadmap. Our training program will focus on minority trainees at all levels and make a difference in the long run by tackling the problem of substance abuse. The overarching goal of the research, training and education programs of this DIDARP are to enhance CDU's capacity to conduct substance abuse research with a primary focus on the metabolic effects of nicotine. The specific goals of CDU DIDARP are: 1. To increase the number of high quality drug addiction research projects related to the metabolic effects of nicotine to allow CDU to develop expertise and acquire preliminary data to be able to compete for NIDA P01, P50 or ROI grants; 2. To continue to foster interest in substance abuse research among under-represented students and other trainees by providing meaningful educational and research experiences; and 3. To continue to enhance the research infrastructure at CDU to support substance abuse research. To achieve these goals, we will have 3 related, cross-disciplinary projects: Project 1: Nicotine exacerbates high fat diet-induced hepatic steatosis and skeletal muscle abnormalities in obese mice. Pilot Project A: Understanding the role of dopamine in binge-eating, nicotine and alcohol use: a translational PET study. Pilot Project B: The association between secondhand smoking and diabetes, obesity and other chronic diseases. Achieving these goals will eventually help reduce the health disparities as related to substance abuse.

Public Health Relevance

Much remains unknown about the devastating consequences of cigarettes and the mechanisms of how nicotine, the main active compound in cigarettes, leads to these effects. The theme of the CDU DIDARP is the 'Metabolic Effects of Nicotine: It Matters' and in one primary project and two pilot projects, we will study the deleterious metabolic effects of nicotine in a multidisciplinary, highly translational manner. Our training program will focus on minority trainees at all levels and we will develop faculty at CDU. The CDU DIDARP, by tackling the problem of cigarette smoking, will have important public health implications.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Resource-Related Research Projects (R24)
Project #
Application #
Study Section
Special Emphasis Panel (ZDA1)
Program Officer
Purohit, Vishnudutt
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Charles R. Drew University of Medicine & Science
Internal Medicine/Medicine
Schools of Medicine
Los Angeles
United States
Zip Code
Liu, Limei; Wang, Ying; Wang, Jian et al. (2018) Enhanced hexose-6-phosphate dehydrogenase expression in adipose tissue may contribute to diet-induced visceral adiposity. Int J Obes (Lond) 42:1999-2011
Sinha-Hikim, Amiya P; Mahata, Sushil K (2018) Editorial: Obesity, Smoking, and Fatty Liver Disease. Front Endocrinol (Lausanne) 9:1
Hasan, Mohammad Kamrul; Friedman, Theodore C; Sims, Carl et al. (2018) ?7-Nicotinic Acetylcholine Receptor Agonist Ameliorates Nicotine Plus High-Fat Diet-Induced Hepatic Steatosis in Male Mice by Inhibiting Oxidative Stress and Stimulating AMPK Signaling. Endocrinology 159:931-944
Kermah, Dulcie; Shaheen, Magda; Pan, Deyu et al. (2017) Association between secondhand smoke and obesity and glucose abnormalities: data from the National Health and Nutrition Examination Survey (NHANES 1999-2010). BMJ Open Diabetes Res Care 5:e000324
Tang, Kechun; Pasqua, Teresa; Biswas, Angshuman et al. (2017) Muscle injury, impaired muscle function and insulin resistance in Chromogranin A-knockout mice. J Endocrinol 232:137-153
Sinha-Hikim, Indrani; Friedman, Theodore C; Falz, Mark et al. (2017) Nicotine plus a high-fat diet triggers cardiomyocyte apoptosis. Cell Tissue Res 368:159-170
Lutfy, K; Parikh, D; Lee, D L et al. (2016) Prohormone convertase 2 (PC2) null mice have increased mu opioid receptor levels accompanied by altered morphine-induced antinociception, tolerance and dependence. Neuroscience 329:318-25
Harris, Kindred K; Zopey, Mohan; Friedman, Theodore C (2016) Metabolic effects of smoking cessation. Nat Rev Endocrinol 12:299-308
Yan, C; Yang, H; Wang, Y et al. (2016) Increased glycogen synthase kinase-3? and hexose-6-phosphate dehydrogenase expression in adipose tissue may contribute to glucocorticoid-induced mouse visceral adiposity. Int J Obes (Lond) 40:1233-41
Wang, Ying; Yan, Chaoying; Liu, Limei et al. (2015) 11?-Hydroxysteroid dehydrogenase type 1 shRNA ameliorates glucocorticoid-induced insulin resistance and lipolysis in mouse abdominal adipose tissue. Am J Physiol Endocrinol Metab 308:E84-95

Showing the most recent 10 out of 49 publications