Introduction to the Neuroimaging Core Neuroimaging methodologies allow regional brain structure and function to be assessed non-invasively in humans. In the context of cognitive rehabilitation, neuroimaging methods should be useful in elucidating the regional distribution and pathophysiology of brain injury, as a surrogate marker for categorizing brain injured patients with neuropsychiatric symptoms, and for monitoring regional brain function during therapy. Although the application of neuroimaging methods to rehabilitation research is in its infancy, existing studies clearly demonstrate sensitivity to regional brain dysfunction and a capability for visualizing alterations in regional brain activation in response to pharmacological or physical interventions. The Neuroimaging Core (NC) for the Cognitive Rehabilitation Research Network (CRRN) will focus on magnetic resonance methods, since these methods are completely non-invasive and provide a tremendous breath of tissue contrast. Because MRI scanners are now available in almost every medical center, imaging methods and markers developed by the NC could be rapidly disseminated to other sites. The NC will be located at the University of Pennsylvania which has extensive facilities within the Departments of Neurology, Radiology, and the Center for Cognitive Neuroscience for magnetic resonance neuroimaging. These facilities include research MRI scanners operating at 1.5 Tesla and 4.0 Tesla and several computer labs equipped for image analysis. The primary purpose of the NC will be to provide support for functional neuroimaging experiments proposed in the Scientific Projects, as well as support for collaborative projects which will develop with outside institutions and investigators. In addition, since the use and significance of functional MRI in the presence of neuropathology has not been extensively examined, the NC will also carry out Core research which will focus on the validation of clinical functional MRI methods used for the CRRN.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Resource-Related Research Projects (R24)
Project #
1R24HD039621-01
Application #
6401480
Study Section
Special Emphasis Panel (ZHD1)
Project Start
2000-09-28
Project End
2005-06-30
Budget Start
Budget End
Support Year
1
Fiscal Year
2000
Total Cost
Indirect Cost
Name
Moss Rehabilitation Hospital
Department
Type
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
19141
Kim, Junghoon; Whyte, John; Patel, Sunil et al. (2012) Methylphenidate modulates sustained attention and cortical activation in survivors of traumatic brain injury: a perfusion fMRI study. Psychopharmacology (Berl) 222:47-57
Kim, Junghoon; Whyte, John; Patel, Sunil et al. (2012) A perfusion fMRI study of the neural correlates of sustained-attention and working-memory deficits in chronic traumatic brain injury. Neurorehabil Neural Repair 26:870-80
Kim, Junghoon; Whyte, John; Patel, Sunil et al. (2010) Resting cerebral blood flow alterations in chronic traumatic brain injury: an arterial spin labeling perfusion FMRI study. J Neurotrauma 27:1399-411
Avants, Brian; Duda, Jeffrey T; Kim, Junghoon et al. (2008) Multivariate analysis of structural and diffusion imaging in traumatic brain injury. Acad Radiol 15:1360-75
Whyte, John; Vaccaro, Monica; Grieb-Neff, Patricia et al. (2008) The effects of bromocriptine on attention deficits after traumatic brain injury: a placebo-controlled pilot study. Am J Phys Med Rehabil 87:85-99
Kim, Junghoon; Avants, Brian; Patel, Sunil et al. (2008) Structural consequences of diffuse traumatic brain injury: a large deformation tensor-based morphometry study. Neuroimage 39:1014-26
Kim, Junghoon; Whyte, John; Wang, Jiongjiong et al. (2006) Continuous ASL perfusion fMRI investigation of higher cognition: quantification of tonic CBF changes during sustained attention and working memory tasks. Neuroimage 31:376-85
Roc, Anne C; Wang, Jiongjiong; Ances, Beau M et al. (2006) Altered hemodynamics and regional cerebral blood flow in patients with hemodynamically significant stenoses. Stroke 37:382-7
Whyte, John (2006) Using treatment theories to refine the designs of brain injury rehabilitation treatment effectiveness studies. J Head Trauma Rehabil 21:99-106
Whyte, John; Grieb-Neff, Patricia; Gantz, Christopher et al. (2006) Measuring sustained attention after traumatic brain injury: differences in key findings from the sustained attention to response task (SART). Neuropsychologia 44:2007-14

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