MS (MS) is an important cause of adult disability. Early in the disease course, damage occurs in the brain without disability. As a, many studies have found only a weak correlation between clinical disability and the volume of disease burden on brain MRI. At early stages, therefore, the brain may compensate for damage and stave off disability. These compensatory events have received little attention in MS and are the focus of the proposed pilot studies. Functional imaging studies have provided insights into multiple diseases. In some cases, functional imaging shows changes much between than findings with anatomical studies. Functional MRI (fMRI) is a method for studying brain activation with excellent temporal and spatial resolution. By performing a motor or cognitive task over a course of several minutes, brain areas activated can be identified with great anatomical precision. The proposed project will first develop fMRI paradigms over three domains (cognitive, motor and somatosensory) that are relevant to MS disability and that show low intra-subject variability across time. It will work with the Functional Neuroimaging Core (Core D) of RehabNet- West to test and refine these paradigms, as well as the quantitative interpretation of fMRI data. In the second phase of the project the refined paradigms will be used with MS subjects studied sequentially to determine the correlation of changes in fMRI activation, some of which may be indicative of functional brain plasticity, and disability.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Resource-Related Research Projects (R24)
Project #
1R24HD039629-01
Application #
6401684
Study Section
Special Emphasis Panel (ZHD1)
Project Start
2000-09-28
Project End
2005-06-30
Budget Start
Budget End
Support Year
1
Fiscal Year
2000
Total Cost
Indirect Cost
Name
University of Washington
Department
Type
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
Dobkin, Bruce H (2009) Collaborative models for translational neuroscience and rehabilitation research. Neurorehabil Neural Repair 23:633-40
Dobkin, Bruce H (2009) Progressive Staging of Pilot Studies to Improve Phase III Trials for Motor Interventions. Neurorehabil Neural Repair 23:197-206
Byl, Nancy N; Pitsch, Erica A; Abrams, Gary M (2008) Functional outcomes can vary by dose: learning-based sensorimotor training for patients stable poststroke. Neurorehabil Neural Repair 22:494-504
Regnaux, Jean-Philippe; Saremi, Kaveh; Marehbian, Jon et al. (2008) An accelerometry-based comparison of 2 robotic assistive devices for treadmill training of gait. Neurorehabil Neural Repair 22:348-54
de Bode, Stella; Mathern, Gary W; Bookheimer, Susan et al. (2007) Locomotor training remodels fMRI sensorimotor cortical activations in children after cerebral hemispherectomy. Neurorehabil Neural Repair 21:497-508
Ditunno Jr, John F; Barbeau, Hugues; Dobkin, Bruce H et al. (2007) Validity of the walking scale for spinal cord injury and other domains of function in a multicenter clinical trial. Neurorehabil Neural Repair 21:539-50
Dong, Yun; Winstein, Carolee J; Albistegui-DuBois, Richard et al. (2007) Evolution of FMRI activation in the perilesional primary motor cortex and cerebellum with rehabilitation training-related motor gains after stroke: a pilot study. Neurorehabil Neural Repair 21:412-28
Barbeau, H; Elashoff, R; Deforge, D et al. (2007) Comparison of speeds used for the 15.2-meter and 6-minute walks over the year after an incomplete spinal cord injury: the SCILT Trial. Neurorehabil Neural Repair 21:302-6
Dobkin, Bruce H (2007) Curiosity and cure: translational research strategies for neural repair-mediated rehabilitation. Dev Neurobiol 67:1133-47
Dobkin, B; Barbeau, H; Deforge, D et al. (2007) The evolution of walking-related outcomes over the first 12 weeks of rehabilitation for incomplete traumatic spinal cord injury: the multicenter randomized Spinal Cord Injury Locomotor Trial. Neurorehabil Neural Repair 21:25-35

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