The University of Washington will establish a Medical Rehabilitation Research Network that will facilitate high quality research in rehabilitation in the 15-state western region of the United States. This network will (1) promote new rehabilitation research by clinicians and basic scientists, (2) attract talented investigators to the field, (3) foster interactive approaches to questions central to the rehabilitation research, (4) serve as an educational resource to enhance the capabilities interested in rehabilitation research. The network will include two Scientific Resource Cores, an Information Technology Core, and an Administrative Core. It also will fund up to three pilot projects annually that utilize the services of the network's scientific resources. The Experimental Design and Biostatistics Scientific Resource core will respond to the need of many investigations to access expertise regarding the complex environmental design of studies in rehabilitation. One element of this core will be in the design and conduct of research studies in rehabilitation. Second element will be the development of an experimental design course for rehabilitation researchers. A second element will be the development of an experimental design course for rehabilitation researchers. This course, which will be modular in format, will initially be piloted on-site as an intensive short course in the University of Washington. As the course modules are refined, they will be made available as interactive Web-based learning modules. The Functional Imaging Scientific Resource core will be based at the Brain Mapping Center of the University of California in Los Angeles (UCLA). This core will provide expertise on the design, implementation, and analysis of experimental studies of the nervous system that use functional magnetic resonance imaging (fMRI) and transcranial magnetic stimulation. Core scientists at UCLA will assist new investigators to obtain experience and pilot fMRI data. The Information Technology Core will publicize the resources available from the network to rehabilitation researchers in the regions, will implement and manage an interactive Web site on which materials developed by the network can be accessed by rehabilitation researchers, and will provide linkages to information about grant funding sources. Three pilot projects that utilize the Research Resource Cores will be funded during each project period, with a maximum duration of two years each.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Resource-Related Research Projects (R24)
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Study Section
Special Emphasis Panel (ZHD1-RRG-K (06))
Program Officer
Nitkin, Ralph M
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University of Washington
Physical Medicine & Rehab
Schools of Medicine
United States
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Dobkin, Bruce H (2009) Collaborative models for translational neuroscience and rehabilitation research. Neurorehabil Neural Repair 23:633-40
Dobkin, Bruce H (2009) Progressive Staging of Pilot Studies to Improve Phase III Trials for Motor Interventions. Neurorehabil Neural Repair 23:197-206
Byl, Nancy N; Pitsch, Erica A; Abrams, Gary M (2008) Functional outcomes can vary by dose: learning-based sensorimotor training for patients stable poststroke. Neurorehabil Neural Repair 22:494-504
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de Bode, Stella; Mathern, Gary W; Bookheimer, Susan et al. (2007) Locomotor training remodels fMRI sensorimotor cortical activations in children after cerebral hemispherectomy. Neurorehabil Neural Repair 21:497-508
Ditunno Jr, John F; Barbeau, Hugues; Dobkin, Bruce H et al. (2007) Validity of the walking scale for spinal cord injury and other domains of function in a multicenter clinical trial. Neurorehabil Neural Repair 21:539-50
Dong, Yun; Winstein, Carolee J; Albistegui-DuBois, Richard et al. (2007) Evolution of FMRI activation in the perilesional primary motor cortex and cerebellum with rehabilitation training-related motor gains after stroke: a pilot study. Neurorehabil Neural Repair 21:412-28
Barbeau, H; Elashoff, R; Deforge, D et al. (2007) Comparison of speeds used for the 15.2-meter and 6-minute walks over the year after an incomplete spinal cord injury: the SCILT Trial. Neurorehabil Neural Repair 21:302-6
Dobkin, Bruce H (2007) Curiosity and cure: translational research strategies for neural repair-mediated rehabilitation. Dev Neurobiol 67:1133-47
Dobkin, B; Barbeau, H; Deforge, D et al. (2007) The evolution of walking-related outcomes over the first 12 weeks of rehabilitation for incomplete traumatic spinal cord injury: the multicenter randomized Spinal Cord Injury Locomotor Trial. Neurorehabil Neural Repair 21:25-35

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