This project is for the maintenance of the specimen and data base emanating from the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) and Risk Factors in Early Human Atherogenesis (RFEHA) studies (PDAY Archive) so that it can be used effectively by investigators for continued study of atherosclerosis during the next five years. PDAY and RFEHA were investigator-initiated multi-center cooperative studies based on a rigidly developed protocol, which had anatomically standardized samples of aorta and coronary arteries of 3,000 young black and white subjects, age 15-34, who died suddenly of trauma. Risk factor data was also obtained in a majority of the cases. So far these studies have yielded over 75 publications by the PDAY group. These reports in turn have generated a widespread enthusiastic response from investigators throughout the scientific community in the U.S. and abroad. Many of these investigators are currently utilizing or planning to utilize the PDAY Archive as a resource for their studies on atherosclerosis and coronary heart disease. This unique resource, the PDAY Archive, should continue to contribute in important ways to our understanding of atherosclerosis, the underlying cause of coronary heart disease (CHD) and most strokes. CHD and stroke are by far the leading cause of debilitating illnesses and death in this country.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Resource-Related Research Projects (R24)
Project #
5R24HL060808-03
Application #
6184793
Study Section
Special Emphasis Panel (ZHL1-CSR-A (M1))
Project Start
1998-08-01
Project End
2003-07-31
Budget Start
2000-08-01
Budget End
2001-07-31
Support Year
3
Fiscal Year
2000
Total Cost
$124,343
Indirect Cost
Name
Louisiana State University Hsc New Orleans
Department
Pathology
Type
Schools of Dentistry
DUNS #
782627814
City
New Orleans
State
LA
Country
United States
Zip Code
70112
Hixson, James E; Jun, Goo; Shimmin, Lawrence C et al. (2017) Whole Exome Sequencing to Identify Genetic Variants Associated with Raised Atherosclerotic Lesions in Young Persons. Sci Rep 7:4091
Homma, Satoki; Troxclair, Dana A; Zieske, Arthur W et al. (2011) Histological changes and risk factor associations in type 2 atherosclerotic lesions (fatty streaks) in young adults. Atherosclerosis 219:184-90
Hixson, James E; Shimmin, Lawrence C; Montasser, May E et al. (2011) Common variants in the periostin gene influence development of atherosclerosis in young persons. Arterioscler Thromb Vasc Biol 31:1661-7
Bressler, Jan; Shimmin, Lawrence C; Boerwinkle, Eric et al. (2011) Global DNA methylation and risk of subclinical atherosclerosis in young adults: the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study. Atherosclerosis 219:958-62
Rau, Jill C; Deans, Carolyn; Hoffman, Maureane R et al. (2009) Heparin cofactor II in atherosclerotic lesions from the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study. Exp Mol Pathol 87:178-83
Homma, Satoki; Troxclair, Dana A; Zieske, Arthur W et al. (2008) Histological topographical comparisons of atherosclerosis progression in juveniles and young adults. Atherosclerosis 197:791-8