This competing renewal application requests continued support of the MIRDP research and research development program at WSU. During the previous grant period, four Individual Faculty Investigator research projects were supported in addition to Administrative and Research Infrastructure Development components. The overall aim of the MIRDP program is to enhance and augment research and research career development at WSU in neurobehavioral and psychosocial disciplines related to alcohol, drug abuse and mental health (ADM).
The specific aims of the WSU MIRDP research program are to: 1) enhance the existing capacity of select faculty members to conduct rigorous research in ADM disciplines thereby leading to successful applications for ADM funding under research project grant mechanisms; 2) facilitate the development of the ADM research programs of select faculty members and research associates by providing research support, facilities, and services to engage in independent ADM research activities thereby enhancing the research career development of minority faculty and beginning investigators in ADM disciplines; and 3) augment and strengthen the existing institutional research infrastructure in order to provide suitable research-based MIRDP programs for the research mentoring and competitive academic development of minority graduate and undergraduate students who are participating in the research projects of individual MIRDP investigators. In addition, individual plans for faculty research and career development are devised for each MIRDP faculty participant. The individual research activities and research career development plans will also be augmented by, and linked to, the overall institutional MIRDP development plan for strengthening the research infrastructural capacity at WSU in order to conduct rigorous ADM-related research activities. Thus, an important priority of the MIRDP program relating to research career development of minority faculty and minority students is to provide support for academic units, junior faculty, and student programs at WSU in which the ADM research infrastructure is relatively underdeveloped but wherein there exists a significant potential to develop and sustain rigorous ADM-related research activities in the neurosciences, social work and psychosocial career development of minority students, postdoctoral fellows, and faculty.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Resource-Related Research Projects (R24)
Project #
5R24MH047181-05
Application #
2247450
Study Section
Special Emphasis Panel (SRCM (02))
Project Start
1990-09-30
Project End
1998-08-31
Budget Start
1994-09-01
Budget End
1995-08-31
Support Year
5
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Wayne State University
Department
Physiology
Type
Schools of Medicine
DUNS #
City
Detroit
State
MI
Country
United States
Zip Code
48202
Rizk, Natalie N; Myatt-Jones, Javar; Rafols, Jose et al. (2007) Insulin like growth factor-1 (IGF-1) decreases ischemia-reperfusion induced apoptosis and necrosis in diabetic rats. Endocrine 31:66-71
Hill-Pryor, Crystal; Lindsey, DaShawnda; Lapanowski, Karen et al. (2006) The cardiovascular responses to mu opioid agonist and antagonist in conscious normal and obese rats. Peptides 27:1520-6
Elhamdani, Abdeladim; Azizi, Fouad; Artalejo, Cristina R (2006) Double patch clamp reveals that transient fusion (kiss-and-run) is a major mechanism of secretion in calf adrenal chromaffin cells: high calcium shifts the mechanism from kiss-and-run to complete fusion. J Neurosci 26:3030-6
Elhamdani, Abdeladim; Azizi, Fouad; Solomaha, Elena et al. (2006) Two mechanistically distinct forms of endocytosis in adrenal chromaffin cells: Differential effects of SH3 domains and amphiphysin antagonism. FEBS Lett 580:3263-9
Bannon, Michael J (2005) The dopamine transporter: role in neurotoxicity and human disease. Toxicol Appl Pharmacol 204:355-60
Wang, Jun; Bannon, Michael J (2005) Sp1 and Sp3 activate transcription of the human dopamine transporter gene. J Neurochem 93:474-82
Michelhaugh, Sharon K; Vaitkevicius, Henrikas; Wang, Jun et al. (2005) Dopamine neurons express multiple isoforms of the nuclear receptor nurr1 with diminished transcriptional activity. J Neurochem 95:1342-50
Rizk, Natalie; Dunbar, Joseph C (2004) Insulin-mediated increase in sympathetic nerve activity is attenuated by C-peptide in diabetic rats. Exp Biol Med (Maywood) 229:80-4
Tisdale, Ellen J; Kelly, Carmen; Artalejo, Cristina R (2004) Glyceraldehyde-3-phosphate dehydrogenase interacts with Rab2 and plays an essential role in endoplasmic reticulum to Golgi transport exclusive of its glycolytic activity. J Biol Chem 279:54046-52
Rao, Sumangala P; McRae, Crystal; Lapanowski, Karen et al. (2003) Insulin mediated hemodynamic responses in spontaneous hypertensive rats (SHRs): effect of chromosome 4 gene transfer. Clin Exp Hypertens 25:131-42

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