Abstract

Project 2 (Project Leader: Joanne Weinberg) will test the hypotheses that prenatal ethanol exposure in fetal rats alters neuroimmunological functions through fetal programming of the hypothalamic-pituitaryadrenocortical (HPA) axis and that the cellular mechanism by which such i.mmunological effects occur is epigenetic modification of HPA-related gene expression.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Resource-Related Research Projects (R24)
Project #
1R24MH081797-01
Application #
7467623
Study Section
Special Emphasis Panel (ZRG1-RPHB-A (50))
Project Start
Project End
Budget Start
2007-09-27
Budget End
2008-07-31
Support Year
1
Fiscal Year
2007
Total Cost
$120,568
Indirect Cost

  Institution

Name
University of California Berkeley
Department
Type
DUNS #
124726725
City
Berkeley
State
CA
Country
United States
Zip Code
94704

  Publications

Boyce, W Thomas (2017) Epigenomic Susceptibility to the Social World: Plausible Paths to a ""Newest Morbidity"". Acad Pediatr 17:600-606
Sakhai, Samuel A; Saxton, Katherine; Francis, Darlene D (2016) The influence of early maternal care on perceptual attentional set shifting and stress reactivity in adult rats. Dev Psychobiol 58:39-51
Boyce, W Thomas (2016) Differential Susceptibility of the Developing Brain to Contextual Adversity and Stress. Neuropsychopharmacology 41:142-62
Beery, Annaliese K; McEwen, Lisa M; MacIsaac, Julia L et al. (2016) Natural variation in maternal care and cross-tissue patterns of oxytocin receptor gene methylation in rats. Horm Behav 77:42-52
Lussier, Alexandre A; Stepien, Katarzyna A; Neumann, Sarah M et al. (2015) Prenatal alcohol exposure alters steady-state and activated gene expression in the adult rat brain. Alcohol Clin Exp Res 39:251-61
Boyce, W Thomas; Kobor, Michael S (2015) Development and the epigenome: the 'synapse' of gene-environment interplay. Dev Sci 18:1-23
Jiang, Ruiwei; Jones, Meaghan J; Chen, Edith et al. (2015) Discordance of DNA methylation variance between two accessible human tissues. Sci Rep 5:8257
Quas, Jodi A; Yim, Ilona S; Oberlander, Tim F et al. (2014) The symphonic structure of childhood stress reactivity: patterns of sympathetic, parasympathetic, and adrenocortical responses to psychological challenge. Dev Psychopathol 26:963-82
Guendelman, Sylvia; Goodman, Julia; Kharrazi, Martin et al. (2014) Work-family balance after childbirth: the association between employer-offered leave characteristics and maternity leave duration. Matern Child Health J 18:200-8
Essex, Marilyn J; Boyce, W Thomas; Hertzman, Clyde et al. (2013) Epigenetic vestiges of early developmental adversity: childhood stress exposure and DNA methylation in adolescence. Child Dev 84:58-75

Showing the most recent 10 out of 27 publications