? ? This application represents the renewal of National Neurological AIDS Bank (NNAB), a member of the National Neuro-AIDS Tissue Consortium (NNTC). NNAB is a longitudinal study of well-characterized subjects with advanced AIDS and HIV-seronegative (HIV-) subjects, who have agreed to have serial neurological and neuropsychological examinations during their life, and to donate blood, urine and cerebrospinal fluid (CSF) during life and their organs and tissues after their death. NNAB collects these tissues and organs and distributes them to qualified investigators for research into the pathogenesis of Neuro-AIDS. NNAB characterizes its cohort using standardized NNTC protocols in Neuromedicine, Neuropsychology, Psychiatry/Substance Abuse, and Neuropathology, to achieve consensus diagnoses that are monitored by the NNTC Quality Assurance Committees. In addition, NNAB independently collects information that is essential to study the association between co-morbid medical conditions, such as Hepatitis C virus (HCV) infection, hypertension, diabetes, lipid disorders, as well as the adverse effects of retroviral therapy and HIV neurological disease. The NNAB cohort is unique because of its diversity, and reflects the gender, ethnic, and racial distribution of AIDS in Los Angeles. NNAB is 85% male and 15% female; over 60% of our cohort is a member of racial and ethnic minorities, 20% are monolingual in Spanish, and 8% have less than 6 years of education. In this renewal, we plan to expand our cohort, utilizing our collaborations among UCLA Medical Center, Olive View-UCLA Medical Center, Charles R. Drew University, and USC University Hospital. NNAB has stimulated the development of independently funded projects studying CSF viral load, HCV and the nervous system, and magnetic resonance spectroscopy (MRS) as a tool for following HIV neurological disease. These projects and the information they generate further enrich the value of our tissue collection. NNAB provides an increasingly important resource that mirrors the changing face of the AIDS epidemic and is capable of adapting as the needs of investigators dictate. NNAB provides an invaluable resource to the NNTC, the scientific community, and people living with AIDS. ? ?

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Resource-Related Research Projects (R24)
Project #
Application #
Study Section
Special Emphasis Panel (ZNS1-SRB-A (01))
Program Officer
Nunn, Michael
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California Los Angeles
Schools of Medicine
Los Angeles
United States
Zip Code
Mukerji, Shibani S; Misra, Vikas; Lorenz, David R et al. (2018) Impact of Antiretroviral Regimens on Cerebrospinal Fluid Viral Escape in a Prospective Multicohort Study of Antiretroviral Therapy-Experienced Human Immunodeficiency Virus-1-Infected Adults in the United States. Clin Infect Dis 67:1182-1190
Vitomirov, Andrej; Ramirez-Gaona, Miguel; Mehta, Sanjay R et al. (2017) Random shearing as an alternative to digestion for mitochondrial DNA processing in droplet digital PCR. Mitochondrion 32:16-18
Bryant, Alex K; Moore, David J; Burdo, Tricia H et al. (2017) Plasma soluble CD163 is associated with postmortem brain pathology in human immunodeficiency virus infection. AIDS 31:973-979
Var, Susanna R; Day, Tyler R C; Vitomirov, Andrej et al. (2016) Mitochondrial injury and cognitive function in HIV infection and methamphetamine use. AIDS 30:839-48
Levine, Andrew J; Soontornniyomkij, Virawudh; Achim, Cristian L et al. (2016) Multilevel analysis of neuropathogenesis of neurocognitive impairment in HIV. J Neurovirol 22:431-41
Dever, Seth M; Rodriguez, Myosotys; El-Hage, Nazira (2016) ?-Adrenergic receptor gene expression in HIV-associated neurocognitive impairment and encephalitis: implications for MOR-1K subcellular localization. J Neurovirol 22:866-870
Levine, Andrew J; Quach, Austin; Moore, David J et al. (2016) Accelerated epigenetic aging in brain is associated with pre-mortem HIV-associated neurocognitive disorders. J Neurovirol 22:366-75
Cassol, Edana; Misra, Vikas; Morgello, Susan et al. (2015) Altered Monoamine and Acylcarnitine Metabolites in HIV-Positive and HIV-Negative Subjects With Depression. J Acquir Immune Defic Syndr 69:18-28
Dever, Seth M; Rodriguez, Myosotys; Lapierre, Jessica et al. (2015) Differing roles of autophagy in HIV-associated neurocognitive impairment and encephalitis with implications for morphine co-exposure. Front Microbiol 6:653
Horvath, Steve; Levine, Andrew J (2015) HIV-1 Infection Accelerates Age According to the Epigenetic Clock. J Infect Dis 212:1563-73

Showing the most recent 10 out of 75 publications