The interdisciplinary nature of the field of cancer prevention requires a broad spectrum of research skills. In the past 4 years, we have successfully implemented an R25T interdisciplinary training program with emphasis on the interrelationships of human nutrition, exercise, genetics and metabolic pathways in cancer susceptibility and prevention. The objectives of this training program are: (1) To continue to develop and implement a new curriculum and associated new courses to provide trans-disciplinary training in a secondary area to pre- and post-doctoral fellows in Epidemiology, Nutrition, Genetics and Molecular and Cellular Biology, and (2) To provide extensive research experience in the conduct of multidisciplinary cancer prevention research, with emphasis on human nutrition, genetics and metabolic pathways. We propose to train 5 pre- and 3 post-doctoral fellows. Formal coursework and degrees will be given by four participating programs of the University of Washington: Epidemiology, Nutritional Sciences, Public Health Genetics and Molecular and Cellular Biology. Each trainee will complete a new curriculum developed by this R25T in a secondary area outside his/her PhD area. This curriculum is based on existing courses plus 4 new courses developed by this R25T to fill gaps in trans-disciplinary training. Trainees will gain experience in cancer prevention research within three units of the Fred Hutchinson Cancer Research Center: Cancer Prevention, Epidemiology, and Human Biology. Each fellow will have at least two research mentors from different disciplines. An Advisory Committee composed of leaders of the participating programs will select trainees, monitor their progress and advise the Program Director. Trainees who complete this program will have the didactic and research experience to allow them to be knowledgeable investigators on multidisciplinary cancer prevention research projects.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Education Projects (R25)
Project #
Application #
Study Section
Subcommittee G - Education (NCI)
Program Officer
Ogunbiyi, Peter
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Washington
Public Health & Prev Medicine
Schools of Public Health
United States
Zip Code
Gong, J; Nishimura, K K; Fernandez-Rhodes, L et al. (2018) Trans-ethnic analysis of metabochip data identifies two new loci associated with BMI. Int J Obes (Lond) 42:384-390
Jordahl, Kristina M; Randolph, Timothy W; Song, Xiaoling et al. (2018) Genome-Wide DNA Methylation in Prediagnostic Blood and Bladder Cancer Risk in the Women's Health Initiative. Cancer Epidemiol Biomarkers Prev 27:689-695
Duggan, Catherine; Baumgartner, Richard N; Baumgartner, Kathy B et al. (2018) Genetic variation in TNF?, PPAR?, and IRS-1 genes, and their association with breast-cancer survival in the HEAL cohort. Breast Cancer Res Treat 168:567-576
Citronberg, Jessica S; Curtis, Keith R; White, Emily et al. (2018) Association of gut microbial communities with plasma lipopolysaccharide-binding protein (LBP) in premenopausal women. ISME J 12:1631-1641
Kuzma, Jessica N; Hagman, Derek K; Cromer, Gail et al. (2018) Intra-individual variation in markers of intestinal permeability and adipose tissue inflammation in healthy normal weight to obese adults. Cancer Epidemiol Biomarkers Prev :
Kuzma, Jessica N; Cromer, Gail; Hagman, Derek K et al. (2018) Consuming glucose-sweetened, not fructose-sweetened, beverages increases fasting insulin in healthy humans. Eur J Clin Nutr :
Wang, Xiaoliang; Chan, Andrew T; Slattery, Martha L et al. (2018) Influence of Smoking, Body Mass Index, and Other Factors on the Preventive Effect of Nonsteroidal Anti-Inflammatory Drugs on Colorectal Cancer Risk. Cancer Res 78:4790-4799
Citronberg, Jessica S; Wilkens, Lynne R; Le Marchand, Loic et al. (2018) Plasma lipopolysaccharide-binding protein and colorectal cancer risk: a nested case-control study in the Multiethnic Cohort. Cancer Causes Control 29:115-123
Hardikar, Sheetal; Burnett-Hartman, Andrea N; Phipps, Amanda I et al. (2018) Telomere length differences between colorectal polyp subtypes: a colonoscopy-based case-control study. BMC Cancer 18:513
Turcot, Valérie (see original citation for additional authors) (2018) Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nat Genet 50:26-41

Showing the most recent 10 out of 277 publications