The overall goal of the undergraduate and graduate components of our IMSD program is to increase the number of underrepresented minority (URM) students earning PhDs in biomedical sciences. At the undergraduate level, we have focused on activities designed to enable students to excel in foundation courses (chemistry, calculus, and biology);to graduate in biology with GPAs >3.0;and to enter biomedical science PhD programs following graduation. For freshmen and sophomores we developed a structured program of supplemental course work in chemistry and math, a lab skills course, personal and academic advising, and a two quarter requirement for engagement in faculty-mentored research [our Biology Undergraduate Scholars Program (BUSP)]. For selected juniors and seniors (BUSP Honors), we provided opportunities for significant engagement in research projects that take full advantage of the facilities and expertise on the campus. These activities have resulted in increased numbers of BUSP URM students earning a B.S. in biology with a GPA >3.0 (currently in the range of 45-48%) and an average of ~36% of the BUSP Honors students pursuing a biomedical science PhD. In this renewal, our primary goal for the IMSD-supported BUSP/BUSP Honors students is to increase to at least 60%, the number of them who pursue a PhD. To achieve this goal, we propose to expand the pool from which we select the IMSD-funded BUSP students and to provide new program activities designed to engender in students a deeper understanding of research careers and how to get there. The latter will include field trips to visit research labs and meet faculty and graduate students at other research universities;seminars at which URM faculty will speak about their research;discussions with BUSP alums who are pursuing or have completed PhD programs;and discussions with URM senior graduate students who entered Davis as IMSD Graduate Fellows. For the graduate program, our specific aims are to maintain the high success of the IMSD Fellows in advancing to candidacy, reduce the percentage of students who leave the program without earning their PhD from the current 12.5% to less than 10% through more focused mentoring, and use the success of increase the overall acceptance rate of URM students into the 13 participating graduate programs from the current 12.5% to 18% over the next four years.

Public Health Relevance

The goal of our proposal is to increase the diversity of students pursuing a PhD in biomedical sciences and entering a research career. To achieve this goal, we have developed a coordinated series of enrichment and advising activities for underrepresented undergraduates in biological sciences and a series of professional development activities to enhance the skills of underrepresented first year PhD students in biomedical areas.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Education Projects (R25)
Project #
Application #
Study Section
Minority Programs Review Committee (MPRC)
Program Officer
Hagan, Ann A
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California Davis
Schools of Medicine
United States
Zip Code
Rincón, Esther; Rocha-Gregg, Briana L; Collins, Sean R (2018) A map of gene expression in neutrophil-like cell lines. BMC Genomics 19:573
Jiang, Guochun; Nguyen, Don; Archin, Nancie M et al. (2018) HIV latency is reversed by ACSS2-driven histone crotonylation. J Clin Invest 128:1190-1198
Finno, Carrie J; Bordbari, Matthew H; Gianino, Giuliana et al. (2018) An innate immune response and altered nuclear receptor activation defines the spinal cord transcriptome during alpha-tocopherol deficiency in Ttpa-null mice. Free Radic Biol Med 120:289-302
Chung, Nhi; Bogliotti, Yanina S; Ding, Wei et al. (2017) Active H3K27me3 demethylation by KDM6B is required for normal development of bovine preimplantation embryos. Epigenetics 12:1048-1056
Byndloss, Mariana X; Olsan, Erin E; Rivera-Chávez, Fabian et al. (2017) Microbiota-activated PPAR-? signaling inhibits dysbiotic Enterobacteriaceae expansion. Science 357:570-575
Sun, Xiaolin; Wei, Haiying; Young, Dominique E et al. (2017) Differential pulmonary effects of wintertime California and China particulate matter in healthy young mice. Toxicol Lett 278:1-8
Webster, Kaitlyn A; Schach, Ursula; Ordaz, Angel et al. (2017) Dmrt1 is necessary for male sexual development in zebrafish. Dev Biol 422:33-46
Jena, Prasant K; Sheng, Lili; Liu, Hui-Xin et al. (2017) Western Diet-Induced Dysbiosis in Farnesoid X Receptor Knockout Mice Causes Persistent Hepatic Inflammation after Antibiotic Treatment. Am J Pathol 187:1800-1813
Madrigal, Justin L; Stilhano, Roberta; Silva, Eduardo A (2017) Biomaterial-Guided Gene Delivery for Musculoskeletal Tissue Repair. Tissue Eng Part B Rev 23:347-361
Olsan, Erin E; Byndloss, Mariana X; Faber, Franziska et al. (2017) Colonization resistance: The deconvolution of a complex trait. J Biol Chem 292:8577-8581

Showing the most recent 10 out of 62 publications