The goal of this IMSD Proposal is to increase the number of students in graduate training who contribute to diversity in the biomedical research endeavor and promote their successful completion of the PhD degree. Our focus is upon students who have very strong letters of recommendation in terms of their research talents, but who because of weaker scores (GPA, GRE) might not gain admission into a strong biomedical graduate program. We describe a broad recruiting approach and a rigorous admission strategy. The students are extensively mentored throughout their time in the program to enable them to reach their full potential in a relatively short time period. They take an extensive and thorough didactic course in their first summer, along with a lab course designed to expose them to cutting edge technologies. This has the advantage of making these students highly competitive once they begin their rotations. The students are mentored very closely. This includes meetings with the program faculty for tutoring and advising on a weekly basis. In addition they participate fully in all of our mentoring activities for all first year biomedical graduate students. This includes a weekly IMPACT session wherein small groups of students meet with a faculty member to discuss any and all issues pertaining to graduate education, as well as a weekly FOCUS session wherein a small group of students meet with a faculty member to analyze and discuss a recent paper from the literature. Here the goal is to become entirely comfortable with gaining information from the literature rather than from a textbook. To enhance oral presentation as well as critical thinking skills, students participate in the IMSD journal club each spring. Finally, and in the long run most important, the IMSD students rotate through faculty laboratories as they choose the lab for their thesis research. We provide a performance-based program so that students exit the IMSD program after a one or two year period, depending on individual progress. So far all of our students are in good standing and progressing well, with one exception as a consequence of a serious illness.
This program is dedicated towards an important societal goal, namely increasing the number of UR individuals who enter graduate school to do research in Biomedical Science. We propose to do this by an extensive, creative and carefully mentored step by step process of research and training. The ultimate goal is to increase the number of these individuals in the Biomedical Workforce.
|Infante Lara, Lorena; Fenner, Sabine; Ratcliffe, Steven et al. (2018) Coupling the core of the anticancer drug etoposide to an oligonucleotide induces topoisomerase II-mediated cleavage at specific DNA sequences. Nucleic Acids Res 46:2218-2233|
|Elion, David L; Jacobson, Max E; Hicks, Donna J et al. (2018) Therapeutically Active RIG-I Agonist Induces Immunogenic Tumor Cell Killing in Breast Cancers. Cancer Res 78:6183-6195|
|Elion, David L; Cook, Rebecca S (2018) Genetic and Phenotypic Diversification of Heterogeneous Tumor Populations. Trends Mol Med 24:655-656|
|Durbin, Matthew D; Cadar, Adrian G; Chun, Young Wook et al. (2018) Investigating pediatric disorders with induced pluripotent stem cells. Pediatr Res 84:499-508|
|Kharade, Sujay V; Kurata, Haruto; Bender, Aaron M et al. (2018) Discovery, Characterization, and Effects on Renal Fluid and Electrolyte Excretion of the Kir4.1 Potassium Channel Pore Blocker, VU0134992. Mol Pharmacol 94:926-937|
|Elmore, Zachary C; Guillen, Rodrigo X; Gould, Kathleen L (2018) The kinase domain of CK1 enzymes contains the localization cue essential for compartmentalized signaling at the spindle pole. Mol Biol Cell 29:1664-1674|
|Fisher, Nicole M; Gogliotti, Rocco G; Vermudez, Sheryl Anne D et al. (2018) Genetic Reduction or Negative Modulation of mGlu7 Does Not Impact Anxiety and Fear Learning Phenotypes in a Mouse Model of MECP2 Duplication Syndrome. ACS Chem Neurosci 9:2210-2217|
|Cambronero, Francis E; Liu, Dandan; Neal, Jacquelyn E et al. (2018) APOE genotype modifies the association between central arterial stiffening and cognition in older adults. Neurobiol Aging 67:120-127|
|Alvarado, Gabriela; Ettayebi, Khalil; Atmar, Robert L et al. (2018) Human Monoclonal Antibodies That Neutralize Pandemic GII.4 Noroviruses. Gastroenterology 155:1898-1907|
|Zhang, Zhuzhen; Zi, Zhenzhen; Lee, Eunice E et al. (2018) Differential glucose requirement in skin homeostasis and injury identifies a therapeutic target for psoriasis. Nat Med 24:617-627|
Showing the most recent 10 out of 244 publications