This is a competing renewal application for a short-term research education program originally funded as a T35 in 2000 and as an R25 in 2010. Our major objective is to continue providing annual short-term research education experiences for highly motivated minority students in order to expose them to biomedical research in the area of pulmonary and cardiovascular disease. Locally known as GEMS (Graduate Experiences for Multicultural Students). Over the past 13 years, >170 UG students participated; >115 supported by the T35/R25 and the rest supported by other programs. Collectively, these students have published 81 manuscripts; >60% have earned terminal degrees or are enrolled in professional school. More than 70% of student participants were under-represented ethnic minorities. The program builds upon our established infrastructure and uses the significant strengths of one of the top pulmonary medicine programs in the country. We continue the tradition of addressing the pipeline by requesting 10 undergraduate and 4 health professional student slots. We will also emphasize the concept of team science that is so critical to success in the biomedical research field. Here, in addition to the usual didactic and hands-on research activities, we propose a new model of training that deviates from the traditional mentor/mentee relationship; a paradigm shift where we introduce the concept of academic coaches. A coach is not intended to supplant the mentor, but rather complement this relationship, since coaches do not interact with the student on a day-to-day basis. Coaches are experienced faculty members who guide the students through a successful career path and stay in contact beyond the summer internship. Furthermore, to ensure student success, we propose to use social science approaches and provide the students with a toolkit that will create an environment, a community of practice, where they feel safe to talk about personal, academic and professional issues and to bond through shared norms and values. We will use traditional approaches to student selection but will incorporate a set of targeted questions in the application that will aidin selection of students highly motivated to pursue biomedical research. We believe that these approaches will continue the GEMS tradition of excellence in training under- represented students while at the same time enhancing student's academic success beyond the summer GEMS internship.

Public Health Relevance

This short-term internship program at the University of Colorado Anschutz Medical Campus, locally known as GEMS (Graduate Experiences for Multicultural Students) seeks to expose undergraduate and health professional students from diverse and disadvantaged backgrounds to summer laboratory or clinical translational research experiences in order to increase their representation in research related to cardiovascular, pulmonary or hematologic areas. The goal is to create a workforce of health-related researchers who are as diverse as the community they serve. By exposing these students early in their careers, we hope to capture their interest and excite them about the possibilities of biomedical research.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Education Projects (R25)
Project #
5R25HL103286-07
Application #
9026637
Study Section
Special Emphasis Panel (ZHL1)
Program Officer
Scott, Jane
Project Start
2010-07-01
Project End
2020-06-30
Budget Start
2016-07-01
Budget End
2017-06-30
Support Year
7
Fiscal Year
2016
Total Cost
Indirect Cost
Name
University of Colorado Denver
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045
Cohrs, Randall J; Lee, Katherine S; Beach, Addilynn et al. (2017) Targeted Genome Sequencing Reveals Varicella-Zoster Virus Open Reading Frame 12 Deletion. J Virol 91:
Ritchey, Zak; Hollatz, Amanda L; Weitzenkamp, David et al. (2016) Pediatric Cortical Vein Thrombosis: Frequency and Association With Venous Infarction. Stroke 47:866-8
Kohler, Stephanie L; Pham, Michael N; Folkvord, Joy M et al. (2016) Germinal Center T Follicular Helper Cells Are Highly Permissive to HIV-1 and Alter Their Phenotype during Virus Replication. J Immunol 196:2711-22
Miles, Brodie; Miller, Shannon M; Folkvord, Joy M et al. (2015) Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection. Nat Commun 6:8608
Goldenberg, Neil A; Jenkins, Sarah; Jack, Jessica et al. (2013) Arteriopathy, D-dimer, and risk of poor neurologic outcome in childhood-onset arterial ischemic stroke. J Pediatr 162:1041-6.e1
Avasarala, Sreedevi; Bikkavilli, Rama Kamesh; Van Scoyk, Michelle et al. (2013) Heterotrimeric G-protein, G?16, is a critical downstream effector of non-canonical Wnt signaling and a potent inhibitor of transformed cell growth in non small cell lung cancer. PLoS One 8:e76895
Jupille, Henri J; Medina-Rivera, Melisa; Hawman, David W et al. (2013) A tyrosine-to-histidine switch at position 18 of the Ross River virus E2 glycoprotein is a determinant of virus fitness in disparate hosts. J Virol 87:5970-84
Miller, Matthew W; Knaub, Leslie A; Olivera-Fragoso, Luis F et al. (2013) Nitric oxide regulates vascular adaptive mitochondrial dynamics. Am J Physiol Heart Circ Physiol 304:H1624-33
Cicutto, L; Julien, B; Li, N Y et al. (2012) Comparing school environments with and without legislation for the prevention and management of anaphylaxis. Allergy 67:131-7
Eshleman, Emily; Shahzad, Aamir; Cohrs, Randall J (2011) Varicella zoster virus latency. Future Virol 6:341-355

Showing the most recent 10 out of 11 publications