This renewal application is aimed at continuing to prepare physicians for independent careers in the investigation and treatment of childhood psychiatric disorders. Such programs are urgently needed. This need is based on the large number of children affected, the considerable costs to society associated with their care, the limited effectiveness of available treatment and prevention programs, the small number of physician- scientists active in the field, and the potential for significant scientific advances inthe foreseeable future. This grant will make it possible for the faculty of the Yale Child Study Center working with the American Academy of Child and Adolescent Psychiatry (AACAP) and academic leaders across the country, to continue to refine, evaluate and disseminate model research education programs that extend from the first year of medical school through postdoctoral research training and the submission of a K-series Career Development Award. Along the way, participants will be encouraged to pursue advanced degrees. For Yale medical students, this award will support research seminars and medical student research thesis projects. This initiative builds on Yale's long-standing requirement that medical students complete a research thesis project in order to graduate. The medical student component of this award is built around a fellowship program that was initially funded by the Klingenstein Third Generation Foundation (KTGF) in 2001. Based on the success of the fellowship program at Yale, the KTGF has funded nine additional sites across the country since 2004 (Brown, Johns Hopkins, Mayo Clinic, Mt. Sinai, Stanford, and the Universities of California Davis, Maryland, North Carolina, and Vermont). For postdoctoral participants entering the Albert J. Solnit Integrated Child and Adult Psychiatry Research Pathway at Yale, this award will permit us to continue funding intensive periods of research training prior to entering our recently renewed interdisciplinary T32 Institutional Research Training Program. There are currently 12 participants enrolled at this Yale program, and two more have recently matched into its 2011-2017 cohort. The first two physician-scientists who have completed the Yale program to date (members of the 2004- 2010 cohort) graduated with successfully funded K Awards and junior faculty appointments. Similar integrated programs are currently underway at the University of Colorado (since 2005) and the University of Vermont (since 2010). Funds are also requested to support the national independent evaluation of both the KGTF Medical Student Fellowship Programs (at ten sites, evaluation started in 2009) and the Integrated Research Pathway Programs (at three sites, still to come). With the input of national leaders in research training, these two independent evaluation initiatives will be centrally coordinated through the Office of Training, Research and Education of the American Academy of Child and Adolescent Psychiatry.
This renewal application is aimed at continuing to prepare physicians for independent careers in the investigation and treatment of childhood psychiatric disorders. Such training and education programs are urgently needed. This need is based on the large number of children affected, the considerable costs to society associated with their care, the limited effectiveness of available treatment and prevention programs, the small number of physician-scientists active in the field, and the potential for significant scientific advances in the foreseeable future.
| Muhle, Rebecca A; Reed, Hannah E; Aguayo, Patricia et al. (2018) Evaluation and Management of Self-injury in a Child With a Rare Genomic Variant. JAMA Psychiatry 75:524-525 |
| Abbott, Parker W; Gumusoglu, Serena B; Bittle, Jada et al. (2018) Prenatal stress and genetic risk: How prenatal stress interacts with genetics to alter risk for psychiatric illness. Psychoneuroendocrinology 90:9-21 |
| Olten, Baris; Bloch, Michael H (2018) Meta regression: Relationship between antipsychotic receptor binding profiles and side-effects. Prog Neuropsychopharmacol Biol Psychiatry 84:272-281 |
| Frick, Luciana R; Rapanelli, Maximiliano; Jindachomthong, Kantiya et al. (2018) Differential binding of antibodies in PANDAS patients to cholinergic interneurons in the striatum. Brain Behav Immun 69:304-311 |
| Muhle, Rebecca A; Reed, Hannah E; Stratigos, Katharine A et al. (2018) The Emerging Clinical Neuroscience of Autism Spectrum Disorder: A Review. JAMA Psychiatry 75:514-523 |
| Beversdorf, David Q; Stevens, Hanna E; Jones, Karen L (2018) Prenatal Stress, Maternal Immune Dysregulation, and Their Association With Autism Spectrum Disorders. Curr Psychiatry Rep 20:76 |
| Brainstorm Consortium (see original citation for additional authors) (2018) Analysis of shared heritability in common disorders of the brain. Science 360: |
| Hayman, Victoria; Fernandez, Thomas V (2018) Genetic Insights Into ADHD Biology. Front Psychiatry 9:251 |
| Banaschewski, Tobias; Belsham, Brendan; Bloch, Michael H et al. (2018) Supplementation with polyunsaturated fatty acids (PUFAs) in the management of attention deficit hyperactivity disorder (ADHD). Nutr Health :260106018772170 |
| Telang, Shilpa; Walton, Celeste; Olten, Baris et al. (2018) Meta-analysis: Second generation antidepressants and headache. J Affect Disord 236:60-68 |
Showing the most recent 10 out of 218 publications
