This is a renewal proposal describing the Research Training Program for Neurology and Neurosurgery Residents at Massachusetts General Hospital (MGH) and Brigham and Women's Hospital (BWH) of Harvard Medical School (HMS). The program combines the exciting variety of collaborative research opportunities available at these campuses with a dedicated core group of neuroscience mentors aligned in a two tiered system which includes a 'gateway'mentor responsible for the overall career development of the R25 candidate and a 'research'mentor directly responsible for the scientific activities of the candidate. Mentors have been carefully selected on the basis of research activity, experience guiding clinicians in the early stages of successful research careers, and commitment to this program to develop neurology and neurosurgery residents into effective physician-scientists. In addition, a steering committee will closely oversee all aspects of the resident research training experience. This program has already had tremendous success in its first 5 years of funding which has included 23 trainees who have produced numerous high-impact first author publications and earned foundation as well as K12 and K23 funding. This programmatic structure builds on these successes to ensure that neurology and neurosurgical residents obtain the highest level of training possible to launch careers as outstanding physician-scientists.

Public Health Relevance

There is a widely recognized need for translational and clinical research in neurological diseases which can only be met by continuing to train new investigators who will bring innovative solutions to neurological health problems. This application looks to renew a successful program linking the tremendous depth and breadth of research resources available in the Harvard University system to a small group of dedicated senior neuroscientists mentors for the career development of residents.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Education Projects (R25)
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Study Section
Special Emphasis Panel (ZNS1)
Program Officer
Korn, Stephen J
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Massachusetts General Hospital
United States
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Perez-Nievas, Beatriz G; Serrano-Pozo, Alberto (2018) Deciphering the Astrocyte Reaction in Alzheimer's Disease. Front Aging Neurosci 10:114
Boes, Aaron D; Uitermarkt, Brandt D; Albazron, Fatimah M et al. (2018) Rostral anterior cingulate cortex is a structural correlate of repetitive TMS treatment response in depression. Brain Stimul 11:575-581
Chung, David Y; Sugimoto, Kazutaka; Fischer, Paul et al. (2018) Real-time non-invasive in vivo visible light detection of cortical spreading depolarizations in mice. J Neurosci Methods 309:143-146
Lin, Xudong; Duan, Xin; Jacobs, Claire et al. (2018) High-throughput brain activity mapping and machine learning as a foundation for systems neuropharmacology. Nat Commun 9:5142
Zafar, Sahar F; Postma, Eva N; Biswal, Siddharth et al. (2018) Electronic Health Data Predict Outcomes After Aneurysmal Subarachnoid Hemorrhage. Neurocrit Care 28:184-193
Chung, David Y; Mayer, Stephan A; Rordorf, Guy A (2018) External Ventricular Drains After Subarachnoid Hemorrhage: Is Less More? Neurocrit Care 28:157-161
Fanning, Saranna; Haque, Aftabul; Imberdis, Thibaut et al. (2018) Lipidomic Analysis of ?-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment. Mol Cell :
Regenhardt, Robert W; Mecca, Adam P; Flavin, Stephanie A et al. (2018) Delays in the Air or Ground Transfer of Patients for Endovascular Thrombectomy. Stroke 49:1419-1425
Lin, David J; Finklestein, Seth P; Cramer, Steven C (2018) New Directions in Treatments Targeting Stroke Recovery. Stroke 49:3107-3114
Patel, Shaun R; Herrington, Todd M; Sheth, Sameer A et al. (2018) Intermittent subthalamic nucleus deep brain stimulation induces risk-aversive behavior in human subjects. Elife 7:

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