There is a growing need for physician-scientists to translate developments in basic neuroscience into improvement in clinical care. Obtaining funding for basic, clinical, and translational research, however, has become increasingly difficult for clinician investigators. Neurology trainees require protected research time and excellent mentoring during the formative stages of their careers to be able to compete successfully for mentored career (K awards) and other grants. The Columbia University Neurology Department has been a strong proponent of incorporating research into the training experience of residents. Beginning in 1979, the department has had a T32 for a Clinical Neuroscience Training Program (T32 NS07155), which provided funding for PGY4 residents and first year fellows to learn research methodology and conduct research. Since 2002, we have had a Resident Research Mentorship Program that pairs residents with faculty mentors to work on a research project, and since 2011 a scholarly project has been required for all graduating residents. Beginning in March 2010, we have had this R25 research mentorship program. Three neurology residents (one annually) have been selected to participate, of which one (the only to complete the fellowship phase) has already received a K08 award, one has won the AAN Founders Award for 2014, and one has presented a research project at the annual resident research day at Columbia. Our fourth trainee, a neurosurgeon, will begin her project in July 2014. The present proposal describes a plan to continue this formalized resident research experience for at least 1 resident (neurology, neurosurgery, or other resident interested in neuroscience interest) annually who is considered to have exceptional promise to become an independent basic, clinical, or translational neuroscience researcher. The focus will be on a practical, mentor-directed research experience, with limited classroom time, and residents who participate in this program will be optimally situated to compete for mentored career awards (K awards) at the completion of the 2 year training experience bridging residency and fellowship. Dr. Elkind, the Project Director, a tenured Professor of Neurology and Epidemiology at Columbia has independent NIH funding, as well as experience mentoring and reviewing grants, and the faculty of the program are all experienced basic, clinical, or translational researchers. The program will be evaluated primarily by the trainees' success in obtaining K08 and K23 awards, as well as by academic career placement and productivity in publications.

Public Health Relevance

Neurological disorders, including stroke, dementia, epilepsy, and neurodegenerative conditions, are common and cause a significant burden of morbidity and mortality. Laboratory and clinical neuroscience have advanced markedly in recent years, and there is now a growing role for clinician-scientists to translate developments in neuroscience into improvement in clinical care. Training young neurologists at a formative stage of their careers in research methods, and encouraging them to consider research as a career will increase the number of committed, successful clinician-scientists. This Research Education Program will provide talented neurology residents with the opportunity to develop research skills that have a high likelihood of reducing the burden of neurological disease. It will also create a cadre of committed researchers.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Education Projects (R25)
Project #
5R25NS070697-09
Application #
9503075
Study Section
Special Emphasis Panel (ZNS1)
Program Officer
Korn, Stephen J
Project Start
2010-03-15
Project End
2020-06-30
Budget Start
2018-07-01
Budget End
2019-06-30
Support Year
9
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Columbia University (N.Y.)
Department
Neurology
Type
Schools of Medicine
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Reynolds, Alexandra S; Matthews, Elizabeth; Magid-Bernstein, Jessica et al. (2017) Use of early head CT following out-of-hospital cardiopulmonary arrest. Resuscitation 113:124-127
Lengfeld, Justin E; Lutz, Sarah E; Smith, Julian R et al. (2017) Endothelial Wnt/?-catenin signaling reduces immune cell infiltration in multiple sclerosis. Proc Natl Acad Sci U S A 114:E1168-E1177
Reynolds, Alexandra S; Guo, Xiaotao; Matthews, Elizabeth et al. (2017) Post-anoxic quantitative MRI changes may predict emergence from coma and functional outcomes at discharge. Resuscitation 117:87-90
Chung, David Y; Claassen, Jan; Agarwal, Sachin et al. (2016) Assessment of Noninvasive Regional Brain Oximetry in Posterior Reversible Encephalopathy Syndrome and Reversible Cerebral Vasoconstriction Syndrome. J Intensive Care Med 31:415-9