Abstract

The study of olfaction in aging and Alzheimer's disease (AD) is a relatively new area of investigation. It appeal that some AD subject have deficits in order identification which may be due to damage to the olfactory bulb as a result of abnormal detoxification mechanisms. Studies will determine whether the various enzymes in this detoxification pathway are either suppressed or activated in post-mortem tissues from AD patients and normal age-matched controls. The implications of this study would suggest possible mechanisms for the etiology of AD. It may be possible to monitor these enzyme markers in biopsies olfactory epithelium from AD patients.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Unknown (R35)
Project #
5R35AG007918-05
Application #
3768220
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
University of California Irvine
Department
Type
DUNS #
161202122
City
Irvine
State
CA
Country
United States
Zip Code
92697

  Publications

Cribbs, D H; Pike, C J; Weinstein, S L et al. (1997) All-D-enantiomers of beta-amyloid exhibit similar biological properties to all-L-beta-amyloids. J Biol Chem 272:7431-6
Gomez-Pinilla, F; Miller, S; Choi, J et al. (1997) Heparan sulfate potentiates the autocrine action of basic fibroblast growth factor in astrocytes: an in vivo and in vitro study. Neuroscience 76:137-45
Ulas, J; Cotman, C W (1997) Decreased expression of N-methyl-D-aspartate receptor 1 messenger RNA in select regions of Alzheimer brain. Neuroscience 79:973-82
Cribbs, D H; Kreng, V M; Anderson, A J et al. (1996) Cross-linking of concanavalin A receptors on cortical neurons induces programmed cell death. Neuroscience 75:173-85
Anderson, A J; Su, J H; Cotman, C W (1996) DNA damage and apoptosis in Alzheimer's disease: colocalization with c-Jun immunoreactivity, relationship to brain area, and effect of postmortem delay. J Neurosci 16:1710-9
Cummings, B J; Head, E; Afagh, A J et al. (1996) Beta-amyloid accumulation correlates with cognitive dysfunction in the aged canine. Neurobiol Learn Mem 66:11-23
Su, J H; Cummings, B J; Cotman, C W (1996) Plaque biogenesis in brain aging and Alzheimer's disease. I. Progressive changes in phosphorylation states of paired helical filaments and neurofilaments. Brain Res 739:79-87
Ulas, J; Cotman, C W (1996) Dopaminergic denervation of striatum results in elevated expression of NR2A subunit. Neuroreport 7:1789-93
Kesslak, J P; Yuan, D; Neeper, S et al. (1995) Vulnerability of the hippocampus to kainate excitotoxicity in the aged, mature and young adult rat. Neurosci Lett 188:117-20
Araujo, D M; Cotman, C W (1995) Differential effects of interleukin-1 beta and interleukin-2 on glia and hippocampal neurons in culture. Int J Dev Neurosci 13:201-12

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