The study of olfaction in aging and Alzheimer's disease (AD) is a relatively new area of investigation. It appeal that some AD subject have deficits in order identification which may be due to damage to the olfactory bulb as a result of abnormal detoxification mechanisms. Studies will determine whether the various enzymes in this detoxification pathway are either suppressed or activated in post-mortem tissues from AD patients and normal age-matched controls. The implications of this study would suggest possible mechanisms for the etiology of AD. It may be possible to monitor these enzyme markers in biopsies olfactory epithelium from AD patients.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Unknown (R35)
Project #
5R35AG007918-05
Application #
3768220
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
1993
Total Cost
Indirect Cost
Name
University of California Irvine
Department
Type
DUNS #
161202122
City
Irvine
State
CA
Country
United States
Zip Code
92697
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